Abstract: Objective To evaluate the clinical value of tuberculosis-interferon gamma release assay （TB-IGRA） in the diagnosis of tuberculosis. Methods A retrospective analysis of the clinical data from 756 hospitalized patients,who received TB-IGRA test from Sep 2015 to Jun 2017,was performed. Results The positive rate of TB-IGRA was 87.31% in TB patients,and the positive rate of TB-IGRA was 85.55% and 90.80% respectively in the patients with pulmonary tuberculosis and extrapulmonary tuberculosis,significantly higher than that in the patients without tuberculosis （P<0.001）; there was significantly higher detectable rate in TB patients by TB-IGRA than by anti-acid staining,detection of TB antibody, and the detection of ADA in hydrothorax and ascites （P<0.001）; there were no statistical differences in the detection level of TB-IGRA between different ages,sex,basic diseases,tuberculosis sites,lymphocyte counts,and tuberculosis activity.Conclusion sTB-IGRA had higher diagnostic value in the detection of pulmonary tuberculosis and extrapulmonary tuberculosis. TB-IGRA can be used as auxiliary diagnosis of tuberculosis.

Key words: TB-IGRA, Anti-acid staining, TB-AB, ADA