Abstract: Objective To study the relationship between interleukin,TNF-αand lung function and immune function in children with bronchial asthma.Methods 178 children with bronchial asthma were divided into acute attack group(n=107) and remission group(n=71),and 83 healthy persons at the same period were enrolled in control group.The serum levels of interleukin [interleukin-2(IL-2),interleukin-4(IL-4)and interleukin-6(IL-6)],tumor necrosis factor-α(TNF-α),lung function related indicators [forced vital capacity(FVC),forced expiratory volume in the first second(FEV₁),FEV1/FVC and peak expiratory flow(PEF)] and immune function related indicators [T lymphocyte subsets(CD4⁺,CD8⁺andCD4⁺/CD8⁺)] were measured.Pearson correlation analysis was used to analyze the relationship between serum inflammatory factors and pulmonary function and immune function.Results The serum levels of IL-2,IL-4,IL-6 and TNF-αwere significantly increased in attack group(P<0.05).The levels of FVC,FEV1,FEV₁/FVC,PEF,CD4⁺and CD4⁺/CD8⁺ were significantly decreased in attack group(P<0.05).There was no significant difference in the levels of CD8⁺ among groups(P>0.05).Pearson correlation analysis showed that serum levels of IL-2,IL-4,IL-6 and TNF-αwere negatively correlated with FVC,FEV₁,FEV₁/FVC,PEF,CD4⁺,CD4⁺/CD8⁺ in attack group and remission group(P<0.05),but no with CD8⁺(P>0.05).Conclusion The levels of interleukin and TNF-αin children with bronchial asthma are significantly increased,while lung function and immune function are significantly reduced.Moreover,interleukin and TNF-αhave a negative correlation with lung function and immune function.The above indicators can be used to evaluate the therapeutic effect of bronchial asthma in children.

Key words: Bronchial asthma, Children Interleukin, Lung function, Immune function, Correlation