Research Progress on the Interaction between Platelets and Neutrophils in Immunothrombosis during Sepsis

doi:10.3969/j.issn.1671-2587.2026.02.022

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2026, Vol. 28 ›› Issue (2): 286-292.DOI: 10.3969/j.issn.1671-2587.2026.02.022

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Research Progress on the Interaction between Platelets and Neutrophils in Immunothrombosis during Sepsis

YE Zhishun^1,2, LI Guanqiu^1,3, WU Changlin^1,4

¹The First Clinical Medical College of Guangdong Medical University, Zhanjiang 524023;
²Transfusion Department, School of Medicine, the Sixth Affiliated Hospital of South China University of Technology (Nanhai District People's Hospital of Foshan), Foshan 528200;
³Transfusion Department, The Eighth Affiliated Hospital of Southern Medical University (Shunde District First People's Hospital of Foshan), Foshan 528300;
⁴Transfusion Department, Shenzhen Second People's Hospital (The First Affiliated Hospital of Shenzhen University), Shenzhen 518035;

Received:2025-06-05 Accepted:2025-08-01 Online:2026-04-20 Published:2026-04-22

Abstract

Abstract: Sepsis is an organ dysfunction syndrome caused by a dysregulated host response to infection, and immunothrombosis is one of its core pathological mechanisms. In recent years, platelet-neutrophil interactions have attracted increasing attention as a key link bridging inflammation and coagulation imbalance. Although research in this area is steadily advancing, there is still a lack of systematic summaries regarding its regulatory mechanisms, clinical evaluation value, and targeted interventions. This review focuses on platelet-neutrophil complexes (PNCs) and neutrophil extracellular traps (NETs), summarizing current progress in their biomaker significance, roles in pathogenesis, activation of regulatory pathways, and potential targeted interventions in sepsis. It also highlights their application prospects in disease assessment and individualized treatment, while addressing the exisiting challenges in mechanistic integration, detection methodologies, and clinical transformation. The aim is to provide theoretical support and research directions for further elucidating the mechanisms of immunothrombosis in sepsis and developing precision treatment strategies.

Key words: Sepsis, Platelet, Neutrophil, Immunothrombosis, Platelet-neutrophil complex, Neutrophil extracellular traps

CLC Number:

R631.2R392.12R364.1

YE Zhishun, LI Guanqiu, WU Changlin. Research Progress on the Interaction between Platelets and Neutrophils in Immunothrombosis during Sepsis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(2): 286-292.

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Research Progress on the Interaction between Platelets and Neutrophils in Immunothrombosis during Sepsis

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