Abstract: Objective To explore the correlation between lipid metabolism and ITP disease, lipid profile in peripheral blood of patients with immune thrombocytopenia (ITP) was detected and analysed , then compared with control group. Methods In this retrospective study, a total of 439 ITP patients and 67 age- and gender-matched healthy controls from the First Affiliated Hospital of Soochow University between January 2021 and August 2023 were enrolled to evaluate the association between lipid profiles and immune thrombocytopenic purpura (ITP) disease activities and response to thrombopoietic drugs. Among the ITP patients, 281 received rhTPO/TPO-RA treatment and were further categorized into responder and non-responder groups based on the Chinese guideline for adult ITP diagnosis and management. The correlation between blood lipid levels and rhTPO/TPO-RA efficacy in these patients was further investigated. Results A total of 439 ITP patients and 67 healthy controls were included in this study, but there was no significant difference in blood lipid levels between the two groups. Among 281 ITP patients who received rhTPO/TPO-RA treatment, the onset time of rhTPO/TPO-RA treatment was shorter (P=0.028 3) and the platelet count elevation was higher (P=0.003 6) in the hyperlipidemia group. Conclusion The therapeutic effect of rhTPO/TPO-RA is better in ITP patients with hyperlipidemia, suggesting that hyperlipidemia in ITP patients may serve as a predictive marker for the efficacy of rhTPO/TPO-RA treatment.

Key words: Immune thrombocytopenia, RhTPO/TPO-RA, Treatment response, Lipid profile