The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury

doi:10.3969/j.issn.1671-2587.2017.02.034

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2017, Vol. 19 ›› Issue (2): 205-209.DOI: 10.3969/j.issn.1671-2587.2017.02.034

• Orignal Article • Previous Articles

The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury

QIU Li

Binhai Tanggu Blood Station,Tianjin 300456

Received:2016-10-24 Online:2017-04-20 Published:2017-04-24

Abstract

Abstract: Transfusion related acute lung injury（TRALI）,which is defined as the onset of acute lung injury within 6h of transfusion,is the most common cause of transfusion related death worldwide.The two most prevalent pathogenesis of TRALI are antibody mediated and non-antibody mediated. Meanwhile,the two-hit model and threshold model are supported by many animal studies.So the most effective prevention is a restrictive transfusion strategy,and making exclusion policy that exclude high-risk donor with multiparous history can also reduce the incidence of TRALI.In addition,either the clinical department or blood service are discussing if some other strategies such as“patient-tailored transfusion policy”and “pooling of plasma”have value in reducing the incidence of TRALI.

Key words: Transfusion related acute lung injury（TRALI）, Pathogenesis, Prevention policy

CLC Number:

R457.1

QIU Li. The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2017, 19(2): 205-209.

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The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury

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