Abstract: Objective This study was designed to evaluate the efficacy and safety of washed RBCs by WG-XDJ-1 RBC washer in the transfusion treatment. Methods A randomized double blind control trial was conducted.Individuals were randomly divided trial group （55 cases） and control group （54 cases）. The two groups were treated with washed RBCs 2 units prepared by WG-XDJ-1 RBC washer and ACP215 RBC washer respectively. Before and after blood transfusion,we recorded the patients' changes about clinical symptoms and physical signs and also examined blood routine,hepatic and renal functions.The effective rates of blood transfusion was evaluated by intention-to-treat （ITT）analysis and per-protocol（PP） analysis,using χ² test; The adverse transfusion reaction of the 2 groups were compared by χ² test;The preservation period of RBCs of the 2 groups before washing were compared by independent samples t test; Wilcoxon rank sum test was used to compare the liver and kidney function before and after blood transfusion in the experimental group. Results According to ITT analysis,the effective rates of trial and control groups were 78.94%,71.93% and there was no difference between trial and control groups （P>0.05）; According to PP analysis,the effective rates of trial and control groups were 81.81%,75.93% and there was no difference between trial and control groups （P>0.05）.The preservation period of RBCs of trial and control groups were 7.037±0.823 days and 7.204±0.877 days and there was no difference between trial and control groups （P>0.05）.The incidences of adverse transfusion reaction were 0.00% and 1.85% for trial and control groups.There was no difference between trial and control groups （P>0.05）.There was no difference in hepatic and renal functions before and after blood transfusion in the trial group（P>0.05）. Conclusion The transfusion treatment with washed RBCs prepared by WG-XDJ-1 RBC washer was effective and well tolerated.

Key words: RBC washer, Washed RBC, Blood transfusion