Abstract: Objective To study the clinical therapeutic effect of plasma exchange on crescent type glomerulonephritis. Methods The cases of crescent type glomerulonephritis defined by renal biopsy were selected,including the early patients with rapidly progressive glomerular nephritis （RPGN）. The patients received the treatments of prednisolone sodium succinate,cyclophosphamide and azathioprine as immunosuppressive regimens. Simultaneously,anticoagulation,correction of anemia and plasma exchange treatments were administered. The patients were given dexamethasone and calcium gluconate to prevent allergy and hypocalcemia during the plasma exchange treatment with 2 000 ml of plasma and 60 ml/min on plasma transfusion for 3 times （once every the third day）. Results The patients presented negative GBM antibodies,61g/L of hemoglobin,625 μg/ of Cr,25.2 mmol/L of BUN,and 476 μmol of UA. Conclusions The therapeutic strategy of early plasma exchange,combined with sufficient glucocorticoids,may take effect rapidly and increase the curative rate in the patients with crescent type glomerulonephritis and RPGN.

Key words: Plasma exchange, Rapidly progressive glomerular nephritis, Curative effect