Abstract: Objective To investigate the significance of total cholesterol and creatinine in prognosis of percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI） Methods 68 cases of PCI with AMI in the hospital were collected in 2016-2017. All subjects were divided into two groups of favourable （n=41） and unfavourable prognosis （n=27） according to the occurrence of adverse cardiac events in the follow-up period. The levels of total cholesterol and creatinine were compared before and after treatments. The ROC curve was used to evaluate the prognostic value of the treatments. Results The levels of total cholesterol and creatinine in patients with unfavourable prognosis were significantly elevated compared to those of unfavourable prognosis （P<0.05）. Pearson correlation analysis showed that the incidence of cardiac adverse events following PCI treatments was positively correlated with total cholesterol and creatinine （r=0.246,r=0.451,P<0.05）. ROC curve analysis showed that the detection sensitivity of total cholesterol combined with creatinine in AMI patients after PCI treatments was 81.48%,and the specificity was 85.37%. Conclusion The levels of cholesterol and creatinine are related to the severity of cardiovascular damage,and the combined measurements of total cholesterol and creatinine is useful for prediction of the prognosis of PCI patients with acute myocardial infarction.

Key words: Acute myocardial infarction, Percutaneous coronary intervention, Creatinine, Cholesterol