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临床输血与检验

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (3): 215-217.DOI: 10.3969/j.issn.1671-2587.2016.03.005

• 临床输血研究 • 上一篇    下一篇

1例自身抗体致主侧配血不合G6PD缺乏症严重贫血患儿疗效观察

陈志忠, 李结敏, 余文潮, 谭晓颖, 陈尚良, 赵嘉庆   

  1. 526020 广东省肇庆市中心血站（陈志忠,李结敏,余文潮,谭晓颖,陈尚良）; 端州区妇幼保健院检验科（赵嘉庆）
  • 收稿日期:2015-12-26 出版日期:2016-06-20 发布日期:2016-09-21
  • 通讯作者: 陈尚良,（Tel）13600222026（E-mail）fimmu2000@163.com。
  • 作者简介:陈志忠（1958-）,男,广东肇庆人,副主任技师,本科,主要从采供血管理和输血安全研究,（E-mail）zqchenzhizhong@163.com。

Therapeutic Effect of Blood Transfusion in One Anemia Patient with G6PD Deficiency Caused by Autoantibody

CHEN Zhi-zhong, LI Jie-ming, YU Wen-chao, et al. Zhaoqing Blood Center of Guangdong Province526020   

  • Received:2015-12-26 Online:2016-06-20 Published:2016-09-21

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摘要： 目的为1例自身抗体阳性的葡萄糖-6-磷酸脱氢酶缺乏症(G6PD)贫血患儿筛选合适红细胞血液制剂,纠正其低血红蛋白血症。方法采用微柱凝胶法进行血型鉴定,抗人球蛋白法进行抗体筛查和交叉配血。结果患儿存在自身抗体干扰交叉配血主侧试验,经“盲配”多个供者,为患儿选择了2单位主侧凝集强度小于或者接近自身对照的红细胞进行临床输注。结论自身抗体致主侧配血不合非临床输血的绝对禁忌,输注1.5 U红细胞悬浮液后,患儿血红蛋白得到有效提升。

关键词: 自身抗体, 同种抗体, 输血疗效

Abstract: Objective To select matching red blood cells and promote hemoglobin level for anemia patient with autoantibody caused by G6PD deficiency. Methods Blood group typing, antibody screening and cross matching were tested by micro column gel method. Results Autoantibody was identified in the patient, which caused interference with main side in cross-match. Two units of RBC, whose main side agglutination intensity was lower than or similar to self-control, were selected after cross-matching multiple donors, and transfused to the patient. Conclusions Main side agglutination due to autoantibody is not an absolute contraindication for transfusion, and the hemoglobin of patient is effectively improved after transfusion of 1.5 U RBC.

Key words: Autoantibody, Iso-antibody, Transfusion, efficacy

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