• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (4): 362-364.DOI: 10.3969/j.issn.1671-2587.2016.04.019

• 临床检验研究 • 上一篇    下一篇

冠心病患者检测血浆氨基末端脑钠肽前体及同型半胱氨酸的临床意义

石秀芳, 孙峰, 雷婷, 王萍, 敖家富   

  1. 236800 安徽省亳州市人民医院
  • 收稿日期:2016-02-19 出版日期:2016-08-20 发布日期:2016-08-26
  • 作者简介:石秀芳(1980-),女,主管检验师,硕士,主要从事生化检验诊断工作,(E-mail)925774923@qq.com。

The Clinical Significance of Detecting NT- proBNP and Homocysteine in Patients with Coronary Atherosclerosis

SHI Xiu-fang, SUN Feng, LEI Ting, et al   

  1. Bozhou City People' s Hospital in Anhui Province 236800
  • Received:2016-02-19 Online:2016-08-20 Published:2016-08-26

摘要: 目的探讨冠心病患者检测血浆氨基末端脑钠肽前体及同型半胱氨酸的临床意义。方法根据冠心病严重程度及冠状动脉造影冠脉病变支数分组,分析比较疾病不同程度时血清氨基末端脑钠肽前体及同型半胱氨酸的差异。结果AMI组、UAP组、SAP组及对照组两两比较,NT-proBNP和HCY水平的差异具有统计学意义(P<0.05);冠状动脉一支病变组、二支病变组、多支病变组两两比较,NT-proBNP和HCY水平差异具有统计学意义(P<0.05)。冠心病病情程度越重,病变冠状动脉越多,NT-proBNP和HCY水平升高越明显。结论血清HCY、BNP水平的变化与冠心病疾病严重程度相关,动态监测对于临床指导冠心病的预防、控制具有重要的意义。

关键词: 冠心病, 氨基末端脑钠肽前体, 同型半胱氨酸

Abstract: ObjectiveTo study the clinical significance of detecting NT-proBNP and homocysteine(HCY) in the patients with coronary atherosclerotic heart disease. MethodsAccording to the severity of coronary artery disease and coronary arteriography, 1 1 9 cases were divided into different groups, and 50 healthy persons were used as control group. All cases were individually measured for NT-proBNP and HCY. ResultsThe levels of NT-proBNP and HCY in the groups of AMI ,UAP, and SAP were significantly higher than those in the control group(P<0.05 ), and the highest levels were noted in AMI group (P<0.05 ). The levels of NT-proBNP and HCYvaried significantly in the patients with single, double or multiple vessels disease. ConclusionThe serum NT-proBNP and HCY levels are associated with severity of coronary artery diseases. Detection of both serum components is has clinical significance in appropriate treatments of coronary heart disease.

Key words: Coronary, atherosclerotic, heart, disease, NT-proBNP, Homocysteine

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