• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (1): 73-75.DOI: 10.3969/j.issn.1671-2587.2018.01.025

• 临床检验 • 上一篇    下一篇

急性冠脉综合征患者心肌损伤标志物cTnI、CK-MB、Fib表达与意义*

李硕, 梁晴, 翟秀娟   

  1. 052360 河北省辛集市第一医院(李硕,梁晴), 河北省辛集市中医院(翟秀娟)
  • 收稿日期:2017-11-05 出版日期:2018-02-20 发布日期:2018-02-28
  • 作者简介:李硕(1971-),女,河北辛集人,副主任医师,学士,主要从事肌酸激酶MB亚型检测及其在心肌损伤中的应用研究,(E-mail)mm2230035@126.com。
  • 基金资助:
    *本课题受河北省卫生厅课题(20171508)资助

Expression of CTnI,CK-MB,and Fib and Its Significance in Diagnosis and Assessment of Acute Coronary Syndromes

LI Shuo, LIANG Qing, ZHAI Xiu-juan   

  1. The First Hospital of Xinji,Hebei,052360
  • Received:2017-11-05 Online:2018-02-20 Published:2018-02-28

摘要: 目的 分析肌钙蛋白(cTnI)、肌酸激酶同工酶(CK-MB)及血浆纤维蛋白原(Fib)对急性冠脉综合征(ACS)病情程度的评估价值。方法 将2016年1月~12月就诊的120例ACS患者(ACS组)及30例健康体检者(健康组)作为观察对象,对比两组cTnI、CK-MB及Fib含量差异。同时以ACS的疾病类型,将ACS患者分为由71例不稳定性心绞痛患者组成的UA组,由49例急性心肌梗死患者组成的AMI组。分析两组间cTnI、CK-MB及Fib含量差异。此外,对ACS患者cTnI、CK-MB及Fib含量与冠心病严重程度的相关性进行分析。结果 ACS组cTnI、CK-MB及Fib含量均高于健康组,差异有统计学意义(P<0.05)。同时,AMI组cTnI、CK-MB及Fib含量均高于UA组,差异有统计学意义(P<0.05)。此外,cTnI、CK-MB及Fib含量与冠心病gensini积分均呈正向直线相关性(P<0.05)。结论 ACS发生后cTnI、CK-MB及Fib含量均可明显升高,同时cTnI、CK-MB及Fib含量与ACS严重程度呈正向直线相关性。

关键词: 急性冠脉综合征, 心肌损伤, 肌钙蛋白, 肌酸激酶同工酶, 血浆纤维蛋白原

Abstract: Objective To analyze the expression and significance of troponin(cTnI),creatine kinase isoenzyme(CK-MB) and plasma fibrinogen(Fib) in patients with acute coronary syndromes (ACS). Methods One hundred and twenty patients with ACS and 30 cases of healthy persons were examined for cTnI,CK - MB and Fib from Jan to December 2016. Simultaneously,patients with ACS were subsequently divided into the group of unstable angina (UA,71 cases) and group of acute myocardial infarction (AMI,49 cases),and the Results were compared and correlation of the concentrations of the markers with the severity of disease was analyzed.Results Patients of ACS group presented a higher level of cTnI,CK-MB and Fib compared with the healthy persons(P<0.05). Patients with AMI showed an elevated level of cTnI,CK-MB and Fib when compared with the group UA(P<0.05). Additionally,the serum concentrations of cTnI,CK-MB and Fib are positively correlated to the scores of Gensini in coronary heart disease(P<0.05). Conclusion The level of cTnI,CK-MB and Fib is obviously increased in sera following ACS onset and linearly correlated with the severity of ACS.

Key words: Acute coronary syndrome, Myocardial injury, Troponin, Creatine kinase isoenzyme, Plasma fibrinogen

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