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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (3): 291-293.DOI: 10.3969/j.issn.1671-2587.2018.03.022

• 临床检验 • 上一篇    下一篇

秋水仙碱与痛风患者CA72-4及胃蛋白酶原水平的相关性

曾祖辰,蔡伟娟,程江   

  1. 832000 新疆石河子大学医学院第一附属医院
  • 收稿日期:2018-09-22 出版日期:2018-06-20 发布日期:2018-06-22
  • 通讯作者: 程江，男，主任技师，主要从事临床检验诊断学工作，（E-mail）
  • 作者简介:曾祖辰（1992–），女，检验技师，在读硕士研究生，主要从事临床检验诊断学工作，（Tel）18899532198。

Association of Colchicine and CA72-4 and Pepsinogen Levels in Patients With Gout

ZENG Zu-Chen，CAI Wei-Juan，CHENG Jiang.   

  1. Department of Clinical Laboratory，the First Affiliated Hospital of Medical College of Shihezi University，832000
  • Received:2018-09-22 Online:2018-06-20 Published:2018-06-22

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摘要： 目的 探讨肿瘤标志物CA72-4及胃蛋白酶原（PG）水平与痛风患者秋水仙碱治疗的相关性。方法 2016年1月~2017年7月在本院内分泌科、风湿科住院的痛风患者64例，根据住院前2周内有无服用秋水仙碱分为服用组（30例）与未服用组（34例）。收集患者的一般资料，包括性别、年龄、病程及2组血清学CA72-4和PG水平等检查。为了排除胃肠道等肿瘤，采用电子胃镜、电子肠镜、腹部彩超等进行排查。结果 ①64例患者均有痛风既往史，无肿瘤性疾病；②两组患者性别、年龄、血沉、尿酸、病程、C-反应蛋白（CRP）和降钙素原（PCT）的差别无统计学意义；③服用组CA72-4明显高于非服用组，差异有统计学意义（P<0.05）。服用组停药2周后CA72-4水平明显降低（P<0.05）；④用药期间和停药后PG水平比较，PGI差异有统计学意义，PGII和PGI/PGII的差异无统计学意义。结论 痛风患者秋水仙碱治疗与CA72-4升高可能存在关联，值得临床重视，注意停药后复查CA72-4，以排除秋水仙碱药物对检测结果的影响。秋水仙碱治疗痛风与PGI具有一定的相关性。

关键词: 痛风, 秋水仙碱, CA72-4, 胃蛋白酶

Abstract: Objective To investigate the correlation between tumor markers CA72-4 and pepsin levels and colchicine treatment in gout patients. Methods From January 2016 to July 2017 in 64 cases of gout in Department of Endocrinology and Rheumatology in our hospital，the patients were divided into two group according to whether or not colchicine was taken in the first two weeks before admission. The patient's general data were collected including gender，age，duration of disease，and levels of CA72-4，and pepsin. In order to exclude gastrointestinal and other tumors，electronic gastroscopy，electronic colonoscopy，abdominal color Doppler ultrasound examination were carried out. Results ①64 patients had history of gout and no tumor diseases. ②There was no significant difference between the two groups in sex，age，course of disease，ESR，UA，CRP and PCT. ③CA72-4 group was significantly higher than non - taking group （P<0.05）. After two weeks' withdrawal，the level of CA72-4 decreased significantly，the difference was statistically significant （P<0.05）. ④The difference of PGI between the two groups during the period of medication and after withdrawal was statistically significant，but there was no statistical difference between PGII and PGI/PGII. Conclusion Colchicine treatment in patients with gout may be associated with elevated CA72-4. Check CA72-4 after stopping medication to exclude the impact of drugs on the test results; Colchicine treatment of gout and PGI have a certainly relevance.

Key words: Gout , Colchicine, Carbohydrate antigen72-4 , Pepsin

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