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临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (1): 46-50.DOI: 10.3969/j.issn.1671-2587.2020.01.011

• 临床检验 • 上一篇    下一篇

血浆微RNA-27b-3p、PGR、CA15-3及CEA联合检测在胃癌早期筛查及评估中的应用*

卞晨璐, 徐磊霞, 周锋   

  1. 226500 江苏省如皋市人民医院检验科
  • 收稿日期:2018-10-20 出版日期:2020-02-20 发布日期:2020-02-28
  • 作者简介:卞晨璐(1989–),女,江苏如皋人,检验技师,本科,主要从事临床检验工作,(E-mail)bclrgr@163.com。
  • 基金资助:
    *本课题受江苏省南通市科技计划(指导性)项目(No.GJZ16037)资助

Clinical Application of Combined Detection of Plasma MicroRNA-27b-3p,PGR,CA15-3 and CEA in Early Screening and Malignant Evaluation of Gastric Cancer BIAN

Chen-lu, XU Lei-xia, ZHOU Feng   

  1. Department of laboratory,Rugan peooles Hospital,Jiagsu 226500
  • Received:2018-10-20 Online:2020-02-20 Published:2020-02-28

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摘要： 目的 研究血浆微RNA-27b-3p、胃蛋白酶原比值(pepsinogen ratio,PGR)、癌抗原15-3(CAl5-3)及血清癌胚抗原(carcinoembryonic antigen,CEA)联合检测在胃癌早期筛查及恶性程度评估中的临床应用。方法 选取2012年2月~2013年2月的100例在本院住院的胃癌手术患者为研究对象,另选本院同期体检正常者92例为对照组,分别对患者的TNM肿瘤分期、肿瘤位置、体积、分化程度、转移情况、浸润情况、病理类型、生存情况进行统计,分析RNA-27b-3p、PGR、CA15-3及CEA联合检测对胃癌早期筛查及恶性程度评估价值。结果 研究组患者RNA-27b-3p、CA15-3及CEA水平均明显高于对照组,PGR低于健康人群;不同性别、年龄、肿瘤位置、大小、浸润深度、TNM分期情况、病理类型患者的血清RNA-27b-3p、PGR、CA15-3及CEA水平之间的差异无统计学意义(P>0.05)。淋巴结转移超过12枚、肿瘤复发及5年随访死亡患者的血清RNA-27b-3p、CA15-3及CEA水平明显升高,PGR水平明显降低;患者血清RNA-27b-3p、CA15-3及CEA水平越高,PGR越低,患者淋巴结转移情况、肿瘤复发情况及随访死亡情况越高;血清RNA-27b-3p、PGR、CA15-3及CEA均为结肠癌患者5年生存的独立危险因素。结论 RNA-27b-3p、CA15-3及CEA与胃癌的进展呈现正相关,PGR水平与胃癌进展呈现负相关,RNA-27b-3p、PGR、CA15-3及CEA对胃癌的筛查及进展具有积极的意义。

关键词: 血浆微RNA-27b-3p, 胃蛋白酶原比值, 癌抗原15-3, 癌胚抗原, 胃癌

Abstract: Objective Application of value of Clinical application of combined detection of plasma microRNA-27b-3p, PGR, CA15-3 and CEA in early screening and evaluation of gastric cancer. Methods One hundred patients with gastric cancer who underwent surgery in our hospital from February 2012 to February 2013 were selected as the study subjects. Another 92 patients with normal physical examination were selected as the control group. The tumor stage, tumor location, volume, differentiation degree, metastasis, infiltration, pathological type and survival of patients with TNM were analyzed. RNA-27b-3p, PGR, CA15-3 and CEA combined detection of early screening for gastric cancer and malignancy assessment value were statistically analysed. Results The levels of RNA-27b-3p, CA15-3 and CEA in the study group were significantly higher than those in the control group, while PGR was significantly lower than that in the control group. There was no significant difference in serum RNA-27b-3p, PGR, CA15-3 and CEA levels among patients with different sex, age, tumor location, size, infiltration depth, TNM stage and pathological type (P>0.05). The serum levels of RNA-27b-3p, CA15-3 and CEA in patients with lymph node metastasis exceeding 12, tumor recurrence and 5-year follow-up death were significantly increased, while PGR levels were significantly decreased. The higher the serum levels of RNA-27b-3p, CA15-3 and CEA, the lower the PGR, the higher the lymph node metastasis, tumor recurrence and follow-up death. Clearly, RNA-27b-3p, PGR, CA15-3 and CEA were independent risk factors for five year survival of gastric cancer patients. Conclusion RNA-27b-3p, CA15-3 and CEA were positively correlated with the progression of gastric cancer. PGR level was negatively correlated with the progression of gastric cancer. RNA-27b-3p, PGR, CA15-3 and CEA had positive significance in the screening and progression of gastric cancer.

Key words: MicroRNA-27b-3p, PGR, CA15-3, CEA, Gastric cancer

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