1 Ogawa Y,Kanai-Azuma M,Akimoto Y,et al. Exosome-like vesicles with dipeptidyl peptidase IV in human saliva[J]. Biol Pharm Bull,2008,31(6): 1059-1062. 2 Colombo M,Raposo G,Théry C. Biogenesis,secretion,and intercellular interactions of exosomes and other extracellular vesicles[J]. Annu Rev Cell Dev Biol,2014,30(1):255-289. 3 Logozzi M,De Milito A,Lugini L,et al.High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients[J].PloS One,2009,4(4):e5219. 4 Peinado H,Aleckovic M,Lavotshkin S,et al.Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET[J].Nat Med,2012,18(6):883-891. 5 Nilsson J,Skog J,Nordstrand A,et al.Prostate cancer-derived urine exosomes:a novel approach to biomarkers for prostate cancer[J].Br J Cancer,2009,100(10):1603-1607. 6 Li J,Sherman-Baust C,Tsai-Turton M,et al.Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer[J].BMC Cancer,2009,9:244. 7 Corcoran C,Friel A,Duffy M,et al. Intracellular and extracellular microRNAs in breast cancer[J]. Clin Chem,2011,57(1):18-32 . 8 Silva J,Garcia V,Zaballos A,et al. Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival[J]. Eur Respir J,2011,37(3):617-623 . 9 Ohshima K,Inoue K,Fujiwara A,et al. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line[J]. PLoS ONE,2010,5(10):e13247 . 10 Brase J,Johannes M,Schlomm T,et al. Circulating miRNAs are correlated with tumor progression in prostate cancer[J]. Int J Cancer,2011,128(3):608-616. 11 Taylor DD,Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer[J]. Gynecol Oncol,2008,110(1):13-21. 12 Thery C,Ostrowski M,Segura E. Membrane vesicles as conveyors of immune responses[J]. Nat Rev Immunol,2009,9(8):581-593. 13 Tetta C,Ghigo E,Silengo L,et al. Extracellular vesicles as an emerging mechanism of cell-to-cell communication[J]. Endocrine,2013,44(1):11-19. 14 Simpson RJ,Lim JW,Moritz RL,et al. Exosomes:proteomic insights and diagnostic potential[J]. Expert Rev Proteomics,2009,6(3):267-283. 15 Murray S,Briasoulis E,Linardou H,et al. Taxane resistance in breast cancer: Mechanisms,predictive biomarkers and circumvention strategies[J]. Cancer Treat Rev,2012,38(7):890-903. 16 Bombonati A,Sgroi DC. The molecular pathology of breast cancer progression[J]. Journal of Pathology,2011,223(2,SI):307-317. 17 Kutanzi KR,Yurchenko OV,Beland FA,et al. MicroRNA-mediated drug resistance in breast cancer[J]. Clin Epigenetics,2011,2(2): 171-185. 18 Tekiner TA,Basaga H. Role of microRNA deregulation in breast cancer cell chemoresistance and stemness[J]. Curr Med Chem,2013,20(27): 3358-3369. 19 Zhang HG,Grizzle WE. Exosomes:a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions[J]. Am J Pathol,2014,184(1): 28-41. 20 Juliana CS,Marcelo LR,Luis OS,et al.Exosomes-mediate microRNAs transfer in breast cancer chemoresistance regulation[J].Am J Cancer Res,2016,6(10):2129-2139. 21 Milane L,Singh A,Mattheolabakis G,et al. Exosome mediated communication within the tumor microenvironment[J]. J Control Release,2015,219: 278-294. 22 Chen WX,Cai YQ,Lv MM,et al. Exosomes from docetaxel-resistant breast cancer cells alter chemosensitivity by delivering microRNAs[J]. Tumor Biology,2014,35(10): 9649-9659. 23 Gao M,Miao L,Liu MI,et al.miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1[J]. Oncotarget,2016,7(37): 59714-59726. 24 Zhu Y,Yu F,Jiao Y,et al. Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5[J]. Clin Cancer Res,2011,17(22): 7105-7115. 25 Hu W,Tan C,He Y,et al. Functional miRNAs in breast cancer drug resistance[J]. Onco Targets Ther,2018,11(11): 1529-1541. 26 Chen WX,Liu XM,Lv MM,et al. Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs[J]. Plos One,2014,9(4):e95240. 27 Takahashi RU,Miyazaki H,Ochiya T,et al.The Roles of MicroRNAs in Breast Cancer[J]. Cancers(Basel),2015,7(2): 598-616. 28 Zhu Y,Wu J,Li S,et al. The function role of miR-181a in chemosensitivity to adriamycin by targeting Bcl-2 in low-invasive breast cancer cells[J]. Cell Physiol Biochem,2013,32(5):1225-1237. 29 Gao M,Miao L,Liu M,et al. miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1[J]. Oncotarget,2016,7(37):59714-59726. 30 Wu MY,Fu J,Xiao X,et al. MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer[J]. Cancer Lett,2014,354(2):311-319. 31 Ye FG,Song C,Cao ZG,et al. Cytidine deaminase axis modulated by miR-484 differentially regulates cell proliferation and chemoresistance in breast cancer[J]. Cancer Res,2015,75(7):1504-1515. 32 Ye X,Bai W,Zhu H,et al. MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN[J]. BMB Rep,2014,47(5):268-273. 33 Yu DD,Wu Y,Zhang XH,et al. Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222[J]. Tumour Biol,2016,37(3):3227-3235. 34 Mikamori M,Yamada D,Eguchi H,et al. MicroRNA-155 controls exosome synthesis and promotes gemcitabine resistance in pancreatic ductal adenocarcinoma[J]. Sci Rep,2017,7:42339. 35 左明新,叶爱军,胡欣.多药耐药性相关ATP结合盒转运蛋白[J].国外医学.药学分册,2005(6):365-368. 36 Jia Y,Chen Y,Wang Q,et al. Exosome:emerging biomarker in breast cancer[J]. Oncotarget,2017,8(25): 41717-41733. 37 Lv M-M,Zhu X-Y,Chen W-X,et al. Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein[J]. Tumour Biol,2014,35(11): 10773-10779. 38 Wood SL,Pernemalm M,Crosbie PA,et al.The role of the tumor‐microenvironment in lung cancer‐metastasis and its relationship to potential therapeutic targets[J]. Cancer Treat Rev,2014,40(4): 558-566. 39 Li XQ,Liu JT,Fan LL,et al. Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy:[J]. Oncotarget,2016,7(17):24585-24595. 40 SEQUIST L V,YANG J C,YAMAMOTO N A,et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations[J]. Journal of Clinical Oncology,2013,31(27): 3327-3334. 41 Xia X,Yu S,Li S,et al. Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin[J]. Plos One,2014,9(2):e89534. 42 Qin X-B,Yu S-R,Zhou L-L,et al. Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner[J]. Int J Nanomedicine,2017,12(12): 3721-3733. 43 Wu H,Zhou J-C,Mei S-S,et al. Circulating exosomal microRNA-96 promotes cell proliferation,migration and drug resistance by targeting LMO7[J]. J Cell Mol Med,2017,21(6):1228-1236. 44 Xiang Q,Tang H-F,Yu J,et al. MicroRNA-98 sensitizes cisplatin-resistant human lung adenocarcinoma cells by up-regulation of HMGA2[J]. Pharmazie,2013,68(4): 274-281. 45 Torre l A,Bray F,Siegel RL,et al. Global cancer statistics,2012[J]. CA Cancer J Clin,2015,65(2):87-108. 46 Orditura M,Galizia G,Sforza V,et al. Treatment of gastric cancer[J]. World J Gastroenterol,2014,20(7):1635-1649. 47 Zheng P,Chen L,Yuan X,et al. Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells[J]. Journal of Experimental & Clinical Cancer Research,2017,36(1):53. 48 Yang S-M,Huang C,Li X-F,et al. miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN[J]. Toxicology,2013,306(306): 162-168. 49 Shedden K,Xie XT,Chandaroy P,et al. Expulsion of small molecules in vesicles shed by cancer cells: Association with gene expression and chemosensitivity profiles[J]. Cancer Res,2003,63(15):4331-4337. 50 Wang XY,Zhang H,Bai M,et al. Exosomes serve as nanoparticles to deliver Anti-miR-214 to reverse chemoresistance to cisplatin in gastric cancer[J]. Molecular Therapy,2018,26(3): 774-783. 51 Shao Y,Shen Y,Chen T,et al. The functions and clinical applications of tumor-derived exosomes[J]. Oncotarget,2016,7(37):60736-60751. 52 Zhang S,Zhang Y,QU J,et al. Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells[J]. Brazilian Journal of Medical and Biological Research,2017,51(1): e6472. 53 Ren D,Lin B,Zhang X,et al. Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectalcancer cells via activating STAT3 signaling pathway[J].Oncotarget,2017,8(30): 49807-49823. |