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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (3): 294-296.DOI: 10.3969/j.issn.1671-2587.2018.03.023

• 临床检验 • 上一篇    下一篇

类风湿关节炎置换术后早期感染患者的血清降钙素原水平变化*

秦栎,孔晓明   

  1. 226500 江苏省如皋市人民医院检验科（秦栎）；溧阳市人民医院检验科（孔晓明）
  • 收稿日期:2017-11-15 出版日期:2018-06-20 发布日期:2018-06-22
  • 作者简介:秦栎（1992–），男，江苏如皋人，检验技师，学士，主要从事临检、生化和免疫工作，（Tel）13862916370（E-mail）qsrgrq@163.com。
  • 基金资助:
    本课题受江苏省溧阳市重点研发计划（社会发展）项目（No.LC2015010）资助

Changes of Serum Procalcitonin Levels in Patients with Early Infection after Rheumatoid Arthritis Replacement

QIN Yue，KONG Xiao-ming.   

  1. Department of clinical laboratory，Rugao people's Hospital，Liyang 2265002
  • Received:2017-11-15 Online:2018-06-20 Published:2018-06-22

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摘要： 目的 分析类风湿关节炎置换术后早期感染患者的血清降钙素原水平的变化情况。方法 回顾性分析本院于2016年2月～2017年2月收治的20例类风湿关节炎置换术后早期感染患者作为研究A组，200例类风湿关节炎置换术后未感染患者作为研究B组，40例健康体检者作为研究C组。对比分析三组术后红细胞沉降率、C-反应蛋白、降钙素原、白细胞计数水平、特异性、敏感度、阴性预测值、阳性预测值等。结果 ①研究A组的红细胞沉降率、C-反应蛋白、降钙素原、白细胞计数水平和研究B组比较，明显偏高，差异有统计学意义（P<0.05）；研究B组的红细胞沉降率、C-反应蛋白、降钙素原、白细胞计数水平和研究C组比较，明显偏高，差异有统计学意义（P<0.05）。②类风湿关节炎置换术后早期感染患者的PCT和ESR水平敏感度和WBC、CRP、PCT的敏感度比较，明显较高，PCT的阳性预测率最高。③PCT的AUC为 0.752，截断值为15.70 ng/mL，标准误为0.061，95%CI范围为0.633～0.982。结论 类风湿关节炎置换术后早期感染患者血清降钙素原水平变化可作为诊断标准，截断值为10.50 ng/ml时可作为临床诊断提供参考依据。

关键词: 类风湿关节炎, 早期感染, 血清降钙素原水平, 人工关节置换术

Abstract: Objective To investigate the changes of serum procalcitonin levels in patients with early infection after rheumatoid arthritis replacement. Methods a retrospective analysis of 20 cases of rheumatoid arthritis after replacement of early infection patients as research group A，200 cases of replacement rheumatoid arthritis without postoperative infection in patients with as the study group B，40 healthy subjects served as study group C were carried out in our hospital from February 2016 to February 2017 were. The erythrocyte sedimentation rate，C-reactive protein，procalcitonin，WBC count，specificity，sensitivity，negative predictive value and positive predictive value of the three groups were compared and analyzed. Results 1.Sedimentation rate，C-reactive protein and procalcitonin，replacement of rheumatoid arthritis patients the level of white blood cell count and study group B after infection were compared in patients with early infection of red blood cell group A rheumatoid arthritis after arthroplasty is significantly higher，P<0.05 was statistically significant in patients with red; cells not infected with rheumatoid arthritis with replacement of group B after sedimentation rate，C-reactive protein and procalcitonin，white blood cell count and the level of C subjects，significantly higher，P<0.05 was statistically significant. 2.The sensitivity of the level of PCT and ESR and the sensitivity of WBC，CRP and PCT in patients with early infection after rheumatoid arthritis replacement were significantly higher，and the positive rate of PCT positive was the highest. 3.The AUC of PCT is 0.752，the truncation value is 15.70ng/mL，the standard error is 0.061，and the 95%CI range is from 0.633 to 0.982. Conclusion Serum procalcitonin levels in patients with early infection after rheumatoid arthritis replacement can be used as diagnostic criteria. The cut-off value is 10.50ng/ml，which can be used as a reference for clinical diagnosis.

Key words: Rheumatoid arthritis, Early infection , Serum procalcitonin levels , Artificial joint replacement

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