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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (5): 539-542.DOI: 10.3969/j.issn.1671-2587.2018.05.027

• 临床检验 • 上一篇    下一篇

血清GDF-15和sCD163与2型糖尿病肾病的相关性

农贤刚, 程卫萍   

  1. 537100 广西贵港市中西医结合骨科医院
  • 收稿日期:2018-03-20 出版日期:2018-10-20 发布日期:2018-09-27
  • 作者简介:农贤刚（1971-）,男,壮族,广西贵港人,主管检验技师,主要从事临床生化和免疫检验研究,（Tel）13978541869。

Correlation of Serum GDF-15 and sCD163 in Patientswith Type 2 Diabetic Nephropathy

NONG Xian-gang, CHENG Wei-ping   

  1. Integrative Medicine of Orthopaedic Hospital,Guigang 537100
  • Received:2018-03-20 Online:2018-10-20 Published:2018-09-27

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摘要： 目的 探讨血清生长分化因子-15（GDF-15）和可溶性血红蛋白清道夫受体（sCD163）与2型糖尿病肾病的相关性。方法 选取2014年2月~2016年6月本院内分泌科收治的2型糖尿病患者106例,按照Mogensen分期标准,分为正常白蛋白尿组（32例）、微量白蛋白尿组（35例）、大量白蛋白尿组（39例）,同期进行健康体检合格者40例为对照组。采用ELISA法检测GDF-15及sCD163水平,并与常见临床指标进行相关性分析。结果 糖尿病肾病（DN）各组患者GDF-15和sCD163水平均明显高于对照组,且随DN的进展逐渐升高。相关分析显示,GDF-15、sCD163均分别与病程、FPG、HbAlc、LDL-C、TC、TG、UAER、BUN、Cr呈正相关（P<0.05或P<0.01）,与HDL-C呈负相关（P<0.01）。结论 GDF-15和sCD163在2型糖尿病肾病不同临床阶段有不同程度的升高,与2型糖尿病肾病的发生、发展密切相关。

关键词: 生长分化因子-15, 可溶性血红蛋白清道夫受体, 2型糖尿病肾病

Abstract: Objective To explore the correlation of serum growth differentiation factor-15 （GDF-15） and soluble haemoglobin scavenger receptor （sCD163） in patients with type 2 diabetic nephropathy （DN）. Method A total of 106 patients with type2 diabetes mellitus in the hospital were selected from February 2014 to June 2016 and the subjects were divided into normal albuminuria （n=32）,micro-albuminuria（n=35） and macro-albuminuria groups（n=39） according to Mogensen staging criteria.Additional 40 cases of healthy peoplewere takenas control. The levels of serum GDF-15 and sCD163 were determined by enzyme-linked immunosorbent assay（ELISA）,and the correlations with common clinical index were analyzed. Results The levels of GDF-15 and sCD163 in DN group weresignificantly higher than those of control group,and increased gradually with the progress of diabetic nephropathy. Conclusion analysis showed that GDF-15 and sCD163 werepositively correlated with diabetic durationsand levels of FPG,HbAlc,LDL-c,TC,TG,UAER,BUN and Cr （P<0.05 or P<0.01）,but negatively correlated with HDL-C （P<0.01）. Conclusion The levels of serum GDF-15 and sCD163are elevated and GDF-15 and sCD163 are closely related to the occurrence and development of type 2 diabetic nephropathy.

Key words: Growth differentiation factor-15, Soluble hemoglobin scavenger receptor, Type 2 diabetic, nephropathy

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