• 中国科学论文统计源期刊
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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (3): 280-284.DOI: 10.3969/j.issn.1671-2587.2019.03.016

• 临床检验 • 上一篇    下一篇

振幅整合脑电图在低血糖晚期早产儿脑功能监测中的应用*

马力, 温晓红, 杨海波   

  1. 230061 安徽医科大学第三附属医院，合肥市第一人民医院
  • 收稿日期:2019-01-18 出版日期:2019-06-20 发布日期:2019-06-17
  • 通讯作者: 温晓红,女,主任医师,主要从事儿内科工作,（E-mail）wenxiaohong@163.com。
  • 作者简介:马力（1982-）,女,山东人,硕士,主治医师,主要从事新生儿脑损伤方面研究,（Tel）15955154358（E-mail）512247965@qq.com。
  • 基金资助:
    *本课题受安徽省科技攻关项目（1604a0802093）资助

The Application of Amplitude-Integrated Electroencephalographic Monitoring in Late preterm Infant with Hypoglycemia

MA Li, WEN Xiao-hong, YANG Hai-bo   

  1. Department of Pediatrics.Third Affiliated Hospital of Anhui Medical University, Hefei230061
  • Received:2019-01-18 Online:2019-06-20 Published:2019-06-17

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摘要： 目的 了解低血糖晚期早产儿的振幅整合脑电图（amplitude-integrated electroencephalogram,aEEG）特点,探讨暂时性低血糖对晚期早产儿脑功能的影响。方法 收集2015年1月~2016年3月入住本院NICU的31例低血糖晚期早产儿为低血糖组（血糖值为1.1~2.1 mmol/L,平均1.7±; 0.3 mmol/L,经治疗,血糖均在2小时内正常）,诊断当天或隔天进行aEEG监测;随机选择24例同时期非低血糖晚期早产儿为对照组,生后3天内进行aEEG监测。分析aEEG背景连续性、睡眠-觉醒周期、下界振幅和带宽的变化特点。结果 （1）连续性：两组间背景活动连续性无统计学差异（P=0.756）;（2）睡眠觉醒周期：①总时程：低血糖组77.8±; 20.3分钟,对照组74.9±; 23.8分钟,两组间无统计学差异（t=0.471,P=0.640）;②宽带时程：低血糖组25.2±; 5.9分钟,对照组24.2±; 6.2分钟,两组间无统计学差异（t=0.614,P=0.542）;③窄带时程：低血糖组52.6±; 18.6分钟,对照组50.7±; 21.0分钟,两组间无统计学差异（t=0.335,P=0.739）;（3）下界振幅：两组间窄带下界（P=0.451）无统计学差异;（4）带宽：两组间宽带带宽（P=0.070）和窄带带宽（χ2=1.733,P=0.188）均无统计学差异;（5）成熟度评分：两组间无统计学差异（t=-1.201,P=0.235）。（6）在2岁以内的神经行为评估中,未发现暂时性低血糖造成发育落后。结论 发生低血糖的晚期早产儿,若血糖短时间内能恢复至正常范围,其aEEG无特异性改变。;

关键词: 振幅整合脑电图, 低血糖, 晚期早产儿, 脑损伤

Abstract: Objective To investigate the characteristics of the amplitude-integrated electroencephalogram in the late preterm infants with hypoglycemia, and explore the effect of transient hypoglycemia on the brain function in late preterm infants. Methods From January 2015 to March 2016, 31 cases of late preterm infants with hypoglycemia admitted to our NICU were selected as hypoglycemia group（blood glucose level are 1.1~2.1 mmol/L, average is 1.7±0.3 mmol/L, after treatment, blood glucose return to normal within 2 hours）, all the objects were observed by aEEG monitoring on the day when hypoglycaemia was diagnosed or the day after. Over the same period, 24 cases with normoglycemia matched for gestation were selected randomly as control group, aEEG monitoring were done within 3 days after birth. The continuity of background, sleep-wake cycles, lower margin amplitude and bandwidth of all aEEG tracing were analyzed．Results （1）Continuity: The continuity of background were no significant difference between the two groups （P=0.756）. （2）Cycling: ①The total time history: hypoglycemia group was 77.8±20.3 minutes, the control group was 74.9±23.8 minutes, no statistical difference between the two groups （t=0.471, P=0.640）. ② Broadband time history: hypoglycemia group was 25.2±5.9 minutes, the control group was 24.2±6.2 minutes, no statistical difference between the two groups （t=0.614,P=0.542）. ③ Narrowband time history: hypoglycemia group was 52.6±18.6 minutes, the control group was 50.7±21.0 minutes, no statistical difference between the two groups （t=0.335, P=0.739）. （3）Lower margin amplitude: there was no statistical difference between the two groups in narrowband（P=0.451）. （4）Bandwidth: there were no statistical differences in both broadband （P=0.070） and narrowband（χ2=1.733,P=0.188）between the two groups. （5）Maturity score: there was no statistical difference between the two groups （t=-1.201,P=0.235）. （6）In the neurobehavioral assessment within 2 years of age, transient hypoglycemia was not found to cause developmental delay. Conclusion If the hypoglycemia in late preterm was transient hypoglycemia, there were no specificity aEEG changes.

Key words: Amplitude-integrated electroencephalogram, Hypoglycemia, Late preterm infant, Brain injury

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