• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 568-570.DOI: 10.3969/j.issn.1671-2587.2019.06.003

• 临床检验 • 上一篇    下一篇

甘精胰岛素联合格列美脲对2型糖尿病老年患者血糖控制及SPARC蛋白表达的影响*

鲍家军, 蒋艺兰, 汤小峰, 李建平   

  1. 226500 江苏省如皋市人民医院内分泌科(鲍家军,蒋艺兰,汤小峰);
    南通市海安县人民医院内分泌科(李建平)
  • 收稿日期:2018-05-12 出版日期:2019-12-20 发布日期:2019-12-25
  • 作者简介:鲍家军(1982-),男,江苏如皋人,主治医师,主要从事糖尿病研究,(E-mail)uygvv123@163.com。
  • 基金资助:
    *本课题受江苏省南通市科技计划项目(No.qyz15038)资助

The Efficacy of Insulin Glargine Combined with Glimepiride on Glycemic Control and Levels of SPARC Protein in Elderly Patients with Type 2 Diabetes

BAO Jia-jun, JIANG Yi-lan, TANG Xiao-feng, et al   

  1. Department of Endocrinology,Rugao Hospital of Jiangsu,226500
  • Received:2018-05-12 Online:2019-12-20 Published:2019-12-25

摘要: 目的 探讨甘精胰岛素联合格列美脲对2型糖尿病老年患者血糖控制效果及富含半胱氨酸的酸性分泌蛋白(SPARC)蛋白表达的影响。方法 选取2016年1月~2018年1月在本院接受治疗的126例2型糖尿病患者为研究对象,依照随机数字表分为对照组和观察组,每组63例,对照组给予甘精胰岛素治疗,观察组采用甘精胰岛素联合格列美脲治疗,比较两组患者治疗前和治疗3个月后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HBA1C)及SPARC水平,对比两组患者治疗效果和不良反应发生情况。结果 治疗后对照组有效率为79.4%,观察组有效率为90.5%,差异有统计学意义(P<0.05);治疗前两组患者FBG、2 h PG、HBA1C和SPARC水平的差异均无统计学意义(P>0.05),治疗后两组患者各指标均降低,且观察组FBG、2 hPG、HBA1c和SPARC水平均低于对照组,差异有统计学意义(P<0.05);对照组和观察组均未出现低血糖不良反应。结论 甘精胰岛素联合格列美脲对2型糖尿病老年患者血糖控制效果良好,可降低糖尿病患者胰岛素抵抗,且安全性较高。

关键词: 甘精胰岛素, 格列美脲, 2型糖尿病, 富含半胱氨酸的酸性分泌蛋白

Abstract: Objective To investigate the effect of insulin glargine combined with glimepiride on glycemic control and serum levels of cysteine-rich acidic protein (SPARC) in elderly patients with type 2 diabetes. Methods One hundred and twenty six patients with type 2 diabetes were randomly divided into control group and observation group on average. The patients in the control were given glargine treatment while those in observation group received both insulin glargine and glimepiride. Fasting blood glucose (FBG),2 hour postprandial blood glucose (2 hPG),HbA1c,and SPARC levels were compared between the two groups before and after 3 months of treatments. The effects and adverse reactions of the two groups of patients were compared. Results The effective rate was 79.4% in the control and 90.5% in the observation group after treatments (P<0.05). No significant difference of FBG,2 hPG,HBA1C and SPARC levels was seen between the two groups before treatment (P>0.05). After treatment,however,the levels of FBG,2 hPG,HBA1C,and SPARC in the two groups were significantly decreased (P<0.05). No hypoglycemia occurred in all of the patients. Conclusion The therapeutic effect of insulin glargine combined with glimepiride is promising in glycemic control of elderly patients with type 2 diabetes,which may reduce insulin resistance in diabetic patients with high safety.

Key words: Insulin glargine, Glimepiride, Type 2 diabetes, Cysteine-rich acidic secretory protein

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