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临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (2): 200-202.DOI: 10.3969/j.issn.1671-2587.2020.02.021

• 临床检验 • 上一篇    下一篇

外周血嗜酸性粒细胞与哮喘-慢阻肺重叠的关系研究

王莉, 王小军   

  1. 716000 陕西省延安市延安大学附属医院
  • 收稿日期:2018-05-04 出版日期:2020-04-20 发布日期:2020-04-16
  • 作者简介:王莉（1984-）,女,陕西延安人,硕士,副主任医师,主要从事肺部慢性疾病诊治工作,（Tel）15929612567（E-mail）fengmanlou08@126.com。

Relationship between Counts of Peripheral Eosinophils and Asthma Underlying Chronic Obstructive Pulmonary Diseases

WANG Li, WANG Xiao-jun   

  1. The Hospital of Yan'An University,Yan'An,Shanxi,716000
  • Received:2018-05-04 Online:2020-04-20 Published:2020-04-16

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1038

摘要： 目的 研究外周血嗜酸性粒细胞与哮喘-慢阻肺重叠（ACO）的关系研究。方法 选择本院2016年2月~2018年2月收治的87例ACO患者,根据嗜酸性粒细胞百分比（EOS）划分为嗜酸性粒细胞组（即EOS≥2%）和非嗜酸性粒细胞组（即EOS<2%）。观察外周血嗜酸性粒细胞与ACO患者预后的关系。结果 对比入院基本资料结果显示两组患者在性别、年龄、吸烟指数、病程等方面的差异均无统计学意义,P>0.05;观察两组患者实验室检验结果,发现非嗜酸性粒细胞组的EOS低于嗜酸性粒细胞组,而中性粒细胞/淋巴细胞比例（NLR）、D-二聚体及血清C-反应蛋白（hs-CRP）水平均高于嗜酸性粒细胞组,差异有统计学意义,P<0.05;观察两组的住院例数及1年死亡例数结果发现再住院的比例,嗜酸性粒细胞组的比例升高,差异有统计学意义,P<0.05。而就1年死亡率而言,两组相比差异无统计学意义,P>0.05。结论 外周血嗜酸性粒细胞水平的高低与患者再住院率、D-二聚体、NLR、hs-CRP等因素密切相关,提示该指标的检测在临床具有一定的指导作用。

关键词: 外周血嗜酸性粒细胞, 哮喘-慢阻肺重叠, 中性粒细胞/淋巴细胞比例, 血清C-反应蛋白, D-二聚体

Abstract: Objective To study the count of peripheral eosinophils in patients with asthma underlying chronic obstructive pulmonary diseases （COPD） and explore its significance in prognosis of COPD. Methods Eight seven patients with COPD hospitalized in 2016 and 2018 were divided into group A（EOS≥2%）and group B （EOS<2%）. The relationship was compared between the count of peripheral eosinophils and the prognosis of asthma combined with COPD. Results No difference of gender,age,smoking,and duration was noted between the two groups（P>0.05）. The EOS counts in group B were significantly less than those in group A but NLR,D-dimer and hs-CRP levels were notably higher than group A（P<0.05）. The numbers of inpatients and deaths within one year were found to be increased in group A （P<0.05）. Conclusion The number of eosinophils is closely related to the frequency of re-admission,D-dimer,NLR,and hs-CRP,suggesting its potential clinical significance.

Key words: Peripheral blood eosinophils, Asthma-COPD, NLR, hs-CRP, D-dimer

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