关键词: D-二聚体, FDP, 急性脑梗塞, 深静脉血栓, ROC曲线

Abstract: ObjectiveThe study was to investigate the diagnostic values of FDP and D-dimer in patient with acute cerebral infarction(ACI) and deep vein thrombosis(DVT). MethodsThe plasma concentrations of FDP and D-dimer were retrospectively statistically analysed, which included 295 cases of ACI, 84 cases of DVT,and 300 cases without the above- mentioned diseases were set up as control. ResultsFDP and D-dimerin varied in ACI,DVT and the control(P<0.01). Patients with DVT, compared to those with ACI showed a significant increase(P<0.01).Diagnostic sensitivity of FDP and D-dimer was 21.5% and 36.2% in ACI, and 44.1% and 64.2% in DVT,while negative predictive value was 48.8% and 53.8% in ACI,and 86.1% and 90.4% in DVT. ROC curve analysis suggested that FDP and D-dimer had certain diagnostic value in patients with ACI and DVT. ConclusionPlasma markers of FDP and D-dimer can be used as diagnostic marker of acute vascular thromboembolic diseases, particularly in showing higher negative exclusion value in deep venous thrombosis disease.

Key words: D-dimer, FDP, Acute, cerebral, infarction, Deep, vein, thrombosis, ROC, curve