• 中国科学论文统计源期刊
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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (6): 625-628.DOI: 10.3969/j.issn.1671-2587.2018.06.022

• 临床检验 • 上一篇    下一篇

脑梗死患者红细胞体积分布宽度的变化及临床意义*

李祯, 张之芬, 韩静颖, 刘天璞, 李丽, 鞠瑛   

  1. 250021 山东大学附属省立医院医学检验部
  • 收稿日期:2018-06-11 出版日期:2018-12-20 发布日期:2018-11-12
  • 作者简介:李祯（1987-）,女,山东济南人,检验师,本科,主要从事临床检验工作,（Tel）15168869359。

The Clinical Significance of Red Cell Distribution Width （RDW） in Patients with Cerebral Infarction

LI Zhen, ZHANG Zhi-fen, HAN Jing-ying, et al   

  1. Laboratory Department,Shandong Provincial Hospital of Shandong University,Jinan 250021
  • Received:2018-06-11 Online:2018-12-20 Published:2018-11-12
  • Contact: 鞠瑛,女,主要从事免疫学检验研究工作,（E-mail）juying2003@126.com。
  • Supported by:
    本课题受国家自然科学基金（81000731）; 与山东省优秀中青年科学家奖励基金（B2010YY045）资助

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摘要： 目的 探讨脑梗死患者红细胞分布宽度（red cell distribution width,RDW）水平的变化及临床应用。方法 收集265例脑梗死患者和160例健康对照组外周血,检测脑梗死组和健康对照组RDW水平,利用受试者工作特征曲线确定RDW最佳截点并将脑梗死患者分为低RDW-CV组（RDW<12.65%）和高RDW组（RDW≥12.65%）,分析两组间年龄、性别、活化部分凝血酶时间（APTT）、凝血酶原时间（PT）、D-二聚体（d-dimer,D-D）差异。结果 脑梗死患者RDW水平显著高于健康对照组,差异有统计学意义（Z=-6.518,P<0.001）;采用ROC曲线,将患者分为低RDW-CV组（RDW<12.65%）和高RDW-CV组（RDW≥12.65%）,高RDW组患者的APTT、PT水平显著高于低RDW组（APTT Z=-2.331,P=0.020;PT Z=-2.062,P=0.039）,而D-D水平差异无统计学意义（Z=-1.141,P=0.254）。结论 脑梗死患者的RDW水平显著高于健康对照者,高RDW组APTT、PT水平显著升高提示RDW在脑梗死疾病辅助诊断中有重要意义。

关键词: 脑梗死, 红细胞分布宽度, ROC曲线

Abstract: Objective To investigate the change and clinical application of the red cell distribution width（RDW） in diagnosis of cerebral infarction. Methods Peripheral blood was collected from 265 patients with cerebral infarction and 160 healthy controls and the level of RDW was detected .The recipients operating characteristic curve （ROC curve） was used to determine the best cutoff point of RDW.The patients were divided into low RDW（RDW<12.65%） and high RDW groups（RDW≥12.65%）according to ROC curve. The variation of age,gender,activated partial thromboplastin time（APTT）,prothrombin time （PT）,and D-dimer （D-D） between the two groups were analyzed. Results The RDW level of the patients with cerebral infarction was obviously higher than that of the healthy control （Z=-6.518,P<0.001）. The value of APTT and PT in high RDW group （RDW≥12.65%） was higher （APTT Z=-2.331,P=0.020）than in low RDW group（RDW<12.65%,PT Z=-2.062,P=0.039）. But no significant difference was noted of D-D level between low and high RDW groups （Z=-1.141,P=0.254）. Conclusion The RDW level were increased in the cerebral infarction patients and APTT and PT were elevated,suggesting the role of RDW in the auxiliary diagnosis of cerebral infarction.

Key words: Cerebral, Infarction RDW, ROC curve

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