血清IFN-γ、IL-2、EGF预测鼻咽癌患者放疗敏感性和预后的相关性分析

doi:10.3969/j.issn.1671-2587.2020.03.019

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (3): 300-304.DOI: 10.3969/j.issn.1671-2587.2020.03.019

血清IFN-γ、IL-2、EGF预测鼻咽癌患者放疗敏感性和预后的相关性分析

王海妮, 陈安青

266000 青岛市口腔医院检验科（王海妮）,青岛市立医院检验科（陈安青）

收稿日期:2019-01-17 出版日期:2020-06-20 发布日期:2020-06-13
通讯作者: 陈安青,女,主管技师,学士,主要从事肿瘤标志物的相关性研究。（E-mail）Deceinber660@soho.com。
作者简介:王海妮（1982-）女,山东青岛人,主管技师,硕士,主要从事肿瘤标志物的相关性研究,（E-mail）luhongsh@163.com。

A Correlation Analysis of Serum IFN-γ, IL-2 and EGF in Prediction of Radiotherapy Sensitivity and Prognosis in Patients with Nasopharyngeal Carcinoma

WANG Hai-ni, CHEN An-qing

Department of Clinical Laboratory,Qingdao Stomatological Hospital, Qingdao,Shandong 266000

Received:2019-01-17 Online:2020-06-20 Published:2020-06-13

摘要/Abstract

摘要： 目的分析血清干扰素-γ（IFN-γ）、白介素-2（IL-2）、表皮生长因子（EGF）预测鼻咽癌患者放疗敏感性和预后的相关性。方法选取山东省青岛市市立医院2010年4月~2013年4月收治的86例鼻咽癌患者,同期选取64例在本院门诊接受体检的健康者作为对照组。分析血清IFN-γ、IL-2、EGF与临床病理特征的关系,比较各组血清IFN-γ、IL-2、EGF水平。结果鼻咽癌患者血清IFN-γ、IL-2、EGF水平在不同性别、年龄、病理类型、分化类型、临床分期中比较差异无统计学意义（P>0.05）。鼻咽癌组血清IFN-γ、IL-2水平低于对照组,EGF水平高于对照组（P<0.05）。鼻咽癌患者放疗敏感组血清IFN-γ、IL-2水平高于放疗耐受组,EGF水平低于放疗耐受组（P<0.05）。鼻咽癌患者生存组血清IFN-γ、IL-2水平高于死亡组,EGF水平低于死亡组（P<0.05）。Cox比例风险模型显示,血清EGF水平及放疗敏感性是影响预后的危险因素,IFN-γ、IL-2为保护因素。IFN-γ曲线下面积为0.719、IL-2曲线下面积为0.773、EGF曲线下面积为0.884、联合检测曲线下面积为0.937,联合检测曲线下面积明显高于单个指标。结论血清IFN-γ、IL-2、EGF在鼻咽癌发生发展中有重要作用,其表达水平和鼻咽癌患者放疗敏感性及预后有关,可指导临床治疗方案的选择。

关键词: 鼻咽癌干扰素-γ, 白介素-2, 表皮生长因子, 放疗敏感性, 预后

Abstract: Objective To analyze the correlation of serum interferon-γ(IFN-γ), interleukin-2 (IL-2) and epidermal growth factor (EGF) for prediction of radiotherapy sensitivity and prognosis in patients with nasopharyngeal carcinoma. Methods Eighty six patients with nasopharyngeal carcinoma in the hospital were collected from 2010 to 2013. Simultaneously, sixty four healthy persons were selected as the control group basec on physical examination. Analysis of the relationship between serum IFN-γ, IL-2, and EGF and clinical pathological features,in both groups were compared. Results No significant difference of serum IFN-γ, IL-2 and EGF concentration in patients with nasopharyngeal carcinoma was noted in gender, ages, pathological types, differentiation types and clinical stages (P>0.05). The levels of IFN-γ and IL-2, however, in nasopharyngeal carcinoma group were lower but EGF was higher than those in the control group (P<0.05). High levels of serum IFN-γ and IL-2 and low levels of EGF in the radiotherapy sensitive group of patients with nasopharyngeal carcinoma were seen compared with those in the radiotherapy resistant group, (P<0.05). The Cox proportional hazard model showed that serum EGF level and radiosensitivity were risk factors for prognosis, and IFN-γ and IL-2 were protective factors. IFN-γ, IL - 2 and EGF areas under the curve were 0.719, 0.773 and 0.884, respectively. The joint detection area under the curve was 0.937, which was significantly higher than that of individual indicators. Conclusion The serum levels of IFN-γ, IL-2, EGF are associated with the development of nasopharyngeal carcinoma, indicating the potential significance of the cytokine detection in guidance of clinical treatments and prognosis of nasopharyngeal carcinoma.

Key words: Nasopharyngeal carcinoma Interferon-γ, Interleukin-2, Epidermal growth factor, Radiation sensitivity, Prognosis

中图分类号:

R730.7

王海妮, 陈安青. 血清IFN-γ、IL-2、EGF预测鼻咽癌患者放疗敏感性和预后的相关性分析[J]. 临床输血与检验, 2020, 22(3): 300-304.

WANG Hai-ni, CHEN An-qing. A Correlation Analysis of Serum IFN-γ, IL-2 and EGF in Prediction of Radiotherapy Sensitivity and Prognosis in Patients with Nasopharyngeal Carcinoma[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(3): 300-304.

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血清IFN-γ、IL-2、EGF预测鼻咽癌患者放疗敏感性和预后的相关性分析

A Correlation Analysis of Serum IFN-γ, IL-2 and EGF in Prediction of Radiotherapy Sensitivity and Prognosis in Patients with Nasopharyngeal Carcinoma

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