110例川崎病患儿血栓弹力图检测结果分析

doi:10.3969/j.issn.1671-2587.2021.01.018

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (1): 71-74.DOI: 10.3969/j.issn.1671-2587.2021.01.018

110例川崎病患儿血栓弹力图检测结果分析

邱立娟, 付晓艳, 马曙轩, 王孟键

100045 北京国家儿童医学中心首都医科大学附属北京儿童医院输血科

收稿日期:2019-09-26 发布日期:2021-02-22
通讯作者: 马曙轩,男,主任技师,主要从事儿科输血和输血免疫学研究,（E-mail）masxfwyy@sina.com。
作者简介:邱立娟（1981-）,女,内蒙人,主管技师,学士,主要从事临床输血研究,（E-mail）646961901@qq.com。

Study of Thromboelastography in 110 Children with Kawasaki Disease

QIU Li-juan, FU Xiao-yan, MA Shu-xuan, et al

Department of Transfusion Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Childrens' Health, Beijing 100045

Received:2019-09-26 Published:2021-02-22

摘要/Abstract

摘要： 目的分析川崎病患儿血栓弹力图检测各参数结果,为临床诊断和治疗提供实验室依据。方法选取2016年1月1日~2016年9月30日于北京儿童医院确诊的川崎病患儿110例为实验组,同时选取凝血功能正常的择期手术患儿60例为对照组,回顾性分析其入院首次TEG、凝血三项和血小板计数检测结果,TEG参数包括反应时间（R值）、凝血时间（K值）、角度（α角）、最大振幅（MA值）、估计的溶解百分比（EPL）、MA后30 min溶解百分比（LY30）和综合凝血指数（CI）。结果实验组R值、K值明显低于对照组;实验组α角、MA值、EPL、LY30和CI值均明显高于对照组,差异均有统计学意义（P<0.05）。结论川崎病患儿凝血因子活性升高,纤维蛋白原含量高,血小板数量或功能高,纤溶系统失衡,总体呈现高凝状态。

关键词: 川崎病, 儿童, 血栓弹力图

Abstract: Objective To analyze the characteristics of thromboelastography in children with Kawasaki disease （KD）and provide laboratory evidence for its diagnosis and treatment. Methods A total of 110 children's KD cases in Beijing Children's Hospital from January 1,2016 to September 30,2016 were enrolled as the experimental group,and 60 children undergoing selective operation with normal coagulation function were recruited as the control group. The baseline results of TEG, blood coagulation and platelet count were retrospectively analyzed. TEG parameters include reaction time（R value）,clotting time（K value）,α angle,maximum amplitude（MA value）,estimated percentage of dissolution（EPL）,percentage of dissolution 30 minutes after MA（LY30）and comprehensive coagulation index（CI）. Results The levels of R and K value in the experimental group were significantly lower than those in control group（P<0.01）,and the levels of αangle,MA,EPL,LY30 and CI in the experimental group were significantly higher than those in the control group（P<0.01）. Conclusion Children with KD had increased coagulation factor activity,high fibrinogen content,high platelet number or hyperfunction,and fibrinolytic system was out of balance,which showing a hypercoagulable state overall.

Key words: Kawasaki disease, Children, Thromboelastography

中图分类号:

R725.4R446.11

邱立娟, 付晓艳, 马曙轩, 王孟键. 110例川崎病患儿血栓弹力图检测结果分析[J]. 临床输血与检验, 2021, 23(1): 71-74.

QIU Li-juan, FU Xiao-yan, MA Shu-xuan, et al. Study of Thromboelastography in 110 Children with Kawasaki Disease[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(1): 71-74.

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110例川崎病患儿血栓弹力图检测结果分析

Study of Thromboelastography in 110 Children with Kawasaki Disease

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