非血缘脐血移植术后患者输血情况相关影响因素分析*

doi:10.3969/j.issn.1671-2587.2021.02.006

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (2): 162-166.DOI: 10.3969/j.issn.1671-2587.2021.02.006

非血缘脐血移植术后患者输血情况相关影响因素分析^*

王慧茹, 刘会兰

230001 中国科学技术大学附属第一医院（安徽省立医院）输血科（王慧茹,刘会兰）; 中国科学技术大学附属第一医院（安徽省立医院）血液内科（刘会兰）

收稿日期:2020-08-14 出版日期:2021-04-20 发布日期:2021-04-19
通讯作者: 刘会兰,女,主任医师,副教授,主要从事造血干细胞移植相关研究,（E-mail）huilanl@ustc.edu.cn。
作者简介:王慧茹（1987-）,女,安徽肥东人,主管技师,博士,主要从事输血免疫学相关研究,（E-mail） wanghuiru@ustc.edu.cn。
基金资助:
*本课题受中央高校基本科研业务费专项资金（No.WK9110000027）; 国家自然科学基金（No.81903637）资助

Factors Influencing Blood Transfusion in Patients after Unrelated Umbilical Cord Blood Transplantation

WANG Hui-ru, LIU Hui-lan

Department of Transfusion, The First Affiliated Hospital of USTC, Anhui Provincial Hospital, Hefei 230001

Received:2020-08-14 Online:2021-04-20 Published:2021-04-19

摘要/Abstract

摘要： 目的探讨行非血缘脐血移植术（UCBT）后患者成分输血及剂量的相关影响因素。方法回顾29例行非血缘脐血移植的血液病患者移植后60天内输血信息,将患者分为低剂量输注组：红细胞和血小板输注量总计<18 U;高剂量输注组：红细胞和血小板输注量总计≥18 U。分析患者的移植前临床资料、移植后植入情况、移植后急性移植物抗宿主病（aGVHD）发生以及一年内生存率与临床输血情况的关系。结果 29例患者移植后60天内平均红细胞输注量为（10.97±11.80） U,平均血小板输注量为（7.12±5.06）U,血小板与红细胞的输入量呈显著正相关;高低剂量输注组移植前两组患者临床资料无显著差异,移植后中性粒细胞植入时间与血小板输注量呈正相关（P<0.05）;移植后发生Ⅱ~Ⅳ级aGVHD的患者输注红细胞与血小板显著高于0~I级aGVHD的患者;低剂量输注组一年生存率显著高于高剂量输注组（P<0.05）。结论非血缘脐血移植患者移植后60天内红细胞和血小板输注量与供体植入,移植后aGVHD发生以及移植后生存期显著相关。

关键词: 非血缘脐血移植术, 白血病, 红细胞输注, 血小板输注, 急性移植物抗宿主病

Abstract: Objective To investigate the related factors associated with blood product and its dose in unrelated umbilical cord blood transplantation (UCBT) patients. Methods The blood transfusion data of 29 patients with hematologic diseases undergoing UCBT were reviewed. The patients were divided into two groups: low dose group, a total of red blood cell (RBC) transfusions and platelet transfusions <18 U; high dose group, a total of RBC transfusions and platelet transfusions ≥18 U. The relationship between pre-transplant clinical data, implantation after transplantation, the incidence of acute graft-versus-host disease（aGVHD）, one-year survival rate and blood transfusion were analyzed. Results The average volume of transfused RBCs in 29 patients within 60 days after transplantation was (10.97±11.80) U, and the average volume of transfused platelets was (7.12±5.06) U. There was a significant positive correlation between platelet and RBC transfusions. There was no significant difference in clinical data between the two groups before transplantation. There was a positive correlation between time of neutrophils implantation and platelet transfusions volume (P<0.05). RBC and platelet transfusions in patients with grade Ⅱ~Ⅳ aGVHD after transplantation were significantly higher than those in patients with grade 0 ~Ⅰ acute GVHD. The one-year survival rate in low dose group was significantly higher than that in high dose group (P <0.05). Conclusion The volume of RBC and platelet transfusions in UCBT patients within 60 days after transplantation was significantly correlated with donor implantation, aGVHD and survival after transplantation.

Key words: Unrelated umbilical cord blood transplantation, Leukemia, Red blood cell transfusion, Platelet transfusion, Acute graft versus host disease

中图分类号:

R457

王慧茹, 刘会兰. 非血缘脐血移植术后患者输血情况相关影响因素分析^*[J]. 临床输血与检验, 2021, 23(2): 162-166.

WANG Hui-ru, LIU Hui-lan. Factors Influencing Blood Transfusion in Patients after Unrelated Umbilical Cord Blood Transplantation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(2): 162-166.

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非血缘脐血移植术后患者输血情况相关影响因素分析^*

Factors Influencing Blood Transfusion in Patients after Unrelated Umbilical Cord Blood Transplantation

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