• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (2): 151-156.DOI: 10.3969/j.issn.1671-2587.2022.02.004

• 新生儿血液检测专题 • 上一篇    下一篇

全国住院输血新生儿凝血功能检测指标分析*

牛佳萌, 李雪莲, 柳秋菊, 胡红兵, 屈柯暄, 杨江存   

  1. 710068 陕西西安医学院（牛佳萌）; 陕西省人民医院输血科（杨江存）; 重庆陆军军医大学大坪医院儿科（李雪莲）; 广西桂林医学院附属医院新生儿科（柳秋菊）; 武汉儿童医院输血科（胡红兵）; 云南昆明市儿童医院输血科（屈柯暄）
  • 收稿日期:2021-10-11 发布日期:2022-04-12
  • 通讯作者: 杨江存,男,研究员,硕士生导师,博士,主要从事临床输血工作, （E-mail）yjc65@sina.com。共同通信作者：屈柯暄,女,副主任技师,硕士生导师,硕士,主要从事临床输血工作,（E-mail）420381347@qq.com。
  • 作者简介:牛佳萌（1995-）,女,陕西兴平人,硕士,主要从事临床输血方面研究,（E-mail）njm2013512@163.com。并列第一作者：李雪莲（1971-）,女,副主任护师,主要从事新生儿护理方面研究,（E-mail）1142214873@qq.com。
  • 基金资助:
    *本课题受陕西省科技成果转移与推广计划-获奖成果转化项目（No.2020CGHJ-029）,陕西省人民医院领军人才项目（No.2021LJ-14）资助

Analysis of Coagulation Indexes of Hospitalized Newborns with Blood Transfusion in China

NIU Jia-meng, LI Xue-lian, LIU Qiu-ju, et al   

  1. Xi'an Medical University, Xi'an 710068
  • Received:2021-10-11 Published:2022-04-12

RichHTML

175

PDF

907

摘要： 目的 通过收集分析住院输血新生儿凝血检查的结果,完善住院新生儿“凝血指标参考值”,为新生儿精准医治提供数据支持。方法 收集全国46家医院,5 669例住院新生儿凝血指标数据,分析比较不同胎龄不同日龄新生儿凝血指标变化。结果 （1）不同胎龄组新生儿凝血酶原时间（PT）值随着日龄的增大呈逐渐降低的趋势。相同日龄组间比较PT值随着胎龄的增大逐渐降低,足月儿PT值最低。日龄在0~4天、5~6天和≥16天具有统计学意义,其他日龄组间无差异。（2）不同胎龄组新生儿随着日龄增长国际标准化比值（INR）均呈下降趋势。相同日龄组间比较,日龄在0~4天、5~6天、7~9天、11~13天和≥16天具有统计学意义。（3）随着三组新生儿日龄增大活化部分凝血活酶时间（APTT）值呈下降趋势。相同日龄组间比较,足月组新生儿APTT值最小,而胎龄<32周组APTT值最大。日龄在0~6天、10~12天和≥16天具有统计学意义。（4）随着三组新生儿日龄的增大凝血酶时间（TT）值有下降趋势,组内有统计学意义。相同日龄比较,在日龄为1~2天、3~4天及≥16天三组间TT值比较差异有统计学意义。（5）各胎龄组新生儿随着日龄增大,纤维蛋白原（FIB）值呈波动性增大的趋势。相同日龄FIB随胎龄增大呈增高趋势,在日龄为1~4天、5~6天、11~12天、13~14天和≥16天差异具有统计学意义。结论 不同胎龄不同日龄新生儿凝血功能相关指标变化显著,依据胎龄日龄制定新生儿凝血指标参考范围有助于指导临床对新生儿凝血障碍疾病的诊疗。

关键词: 新生儿, 凝血指标, 参考区间

Abstract: Objective We collected and analyzed the coagulation test results of hospitalized newborns with blood transfusion to improve the reference values of coagulation indexes and to provide data support for precise treatment of newborns. Methods Data were collected about the coagulation indexes of 5 669 hospitalized newborns from 46 hospitals in China, and the changes of coagulation indexes in newborns with different gestational ages and different days-old were compared. Results (1) The PT value of newborns in different gestational age groups decreased gradually with the increase of days-old. Compared with the same days-old group, the PT value gradually decreased with the increase of gestational age, the PT value of full-term infants being the lowest. The days-old of 0~4 days, 5~6 days and ≥16 days were statistically significant, but no difference was observed among other age groups. (2) The INR values of newborns in different gestational age groups declined with the increase of days-old. Compared with the same days-old groups, the days-old of 0~4 days, 5~6 days, 7~9 days, 11~13 days and ≥16 days were statistically significant. (3) The APTT value was found to fall with the increased newborn days-old in the three groups. Compared with the same days-old groups, the APTT value of full-term neonates was the lowest, while that of <32 weeks neonates was the highest. There was statistical significance in the 0~6 days, 10~12 days and ≥16 days. (4) With the newborn days-old in the three groups increased, the TT value had a downward trend, and there was statistical significance in the group. Compared with the same days-old, there were differences in TT values among the three groups with 1~2 days, 3~4 days and ≥16 days. (5) With the increase of days-old, the FIB value of newborns in each gestational age group fluctuated. FIB at the same days-old increased with the increase of gestational age, and had statistical significance at 1~4 days, 5~6 days, 11~12 days, 13~14 days and ≥16 days. Conclusion The coagulation function related indexes of newborns at different gestational ages and different days-old seem to have remarkable changes, which can guide the clinical diagnosis and treatment of neonatal coagulation disorders and help formulate the reference range of neonatal coagulation indexes based on gestational ages and days.

Key words: Newborn, Coagulation index, Reference range

中图分类号: