• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (2): 163-169.DOI: 10.3969/j.issn.1671-2587.2022.02.006

• 新生儿血液检测专题 • 上一篇    下一篇

全国住院输血新生儿肝功能检测指标分析*

马婷, 苏舒, 王李秦, 宋奥微, 孙杨, 杨江存   

  1. 710068 陕西省人民医院输血科（马婷,王李秦,宋奥微,杨江存）; 西安交通大学公共卫生学院,中澳传染病联合研究中心（苏舒）; 陕西省人民医院数据中心（孙杨）
  • 收稿日期:2021-10-11 发布日期:2022-04-12
  • 通讯作者: 杨江存,男,博士,研究员,硕士生导师,主要从事临床输血工作, （E-mail）yjc65@sina.com。共同通信作者：孙杨,女,博士,高级统计师,主要从事数据统计工作及输血数据研究,（E-mail）suny519@163.com。
  • 作者简介:马婷（1988-）,女,重庆人,主管技师,博士在读,主要从事临床输血研究,（E-mail）mating1988527@126.com。并列第一作者：苏舒（1988-）,女,重庆人,博士,助理教授,主要从事卫生统计与流行病研究,（E-mail）shu.su@xjtu.edu.cn。
  • 基金资助:
    *本课题受陕西省科技成果转移与推广计划-获奖成果转化项目（No.2020CGHJ-029）和陕西省人民医院领军人才项目（No.2021LJ-14）资助

Analysis of Liver Function Indexes of Hospitalized Newborns with Blood Transfusion in China

MA Ting, SU Shu, WANG Li-qin, et al   

  1. Department of Transfusion Medicine, Shaanxi Provincial People's Hospital, Xi' an 710068
  • Received:2021-10-11 Published:2022-04-12

RichHTML

3

PDF

482

摘要： 目的 分析不同胎龄不同日龄住院输血新生儿输血前肝功能检测指标,为深入研究不同胎龄新生儿肝功能指标参考范围提供数据支持。方法 本研究采用多中心回顾性调研方式,以全国46家医院2017年1月1日~2018年6月30日收治的5 669例输血新生儿为研究对象,按照统一的数据采集表,采集新生儿住院诊治数据,对采集数据按胎龄分为<32周组,32~36周组,≥37周组三组,分析不同日龄不同胎龄的新生儿输血前肝功能检测指标。结果 （1）ALT结果显示,早产儿两组ALT中位数0~28 d分别为5~8 U/L和8~11 U/L,足月儿ALT较高为11~22 U/L,不同胎龄组内比较差异有统计学意义。相同日龄组间比较,ALT随胎龄增大逐渐增高,足月儿ALT值最高。各组间比较时除日龄13~14 d无差异外,其余日龄组间差异均有统计学意义。（2）不同胎龄新生儿随日龄增大,TBIL及DBIL呈先升高后减低趋势,相同日龄组间比较时,随胎龄增大TBIL及DBIL值更高。（3）三组TP值比较显示,出生后1~2 d下降,随后呈现逐渐上升趋势,不同日龄比较差异均有统计学意义,相同日龄组间比较时,随胎龄增大TP多呈现增高趋势。（4）相同日龄组间比较时,随胎龄增大ALB呈现增长趋势。结论 肝功能指标参考区间与新生儿胎龄和日龄有关,研究不同胎龄不同日龄新生儿肝功能指标范围,有助于提高对新生儿疾病的精准治疗。

关键词: 肝功能, 新生儿, 多中心研究

Abstract: Objective To analyze the reference intervals of liver function index before blood transfusion in hospitalized newborns with different gestational ages and days-old,and complete the "reference value of liver function indexes" of hospitalized newborns. Methods This study adopted a multi-center retrospective survey method,taking 5 669 newborns admitted to 46 hospitals in China from January 1,2017 to June 30, 2018 as the research objects. According to a unified data collection table,the diagnosis and treatment data of hospitalized newborns were collected. The data were divided into three groups according to gestational age：<32 w group,32~36 w group,and ≥37 w group,and the liver function indicators of different days-old and gestational ages were analyzed. Results （1）The results of ALT showed that the median ALT of 0~28 days in the two groups of preterm infants was 5~8 and 8~11 U/L,respectively. The higher ALT of term infants was 11~22 U/L, which was statistically significant among different gestational age groups. ALT increased gradually with gestational age among the same days-old groups,and the ALT value of full-term infants was the highest. There were significant differences among all groups except 13~14 days of age. （2）TBIL and DBIL of newborns with different gestational age increased at first and then decreased with the increase of days-old. TBIL and DBIL were higher with the increase of gestational age in the same days-old group. （3）TP value of the three groups decreased 1~2 days after birth and then showed a gradual upward trend, and there were statistical significance in comparison with different days-old. TP increased with the increase of gestational age in the days-old. （4）ALB increased with the increase of gestational age in the same days-old group. Conclusion The reference range of liver function index is related to neonatal gestational age and days-old. Studying the range of liver function index of neonates with different gestational age and days-old is helpful to improve the accurate treatment of neonatal diseases.

Key words: Liver function, Neonatology, Multicenter study

中图分类号: