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临床输血与检验

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (3): 349-352.DOI: 10.3969/j.issn.1671-2587.2022.03.015

• 临床检验 • 上一篇    下一篇

基于多元线性回归分析母婴因素对脐带血质量参数的影响

邢义高, 张秀涛, 吕玲, 王忠, 高峰, 雒猛   

  1. 250102 山东省细胞组织库（邢义高,张秀涛,吕玲）; 山东省脐带血造血干细胞库（王忠,高峰,雒猛）; 山东省齐鲁干细胞工程有限公司（邢义高,张秀涛,吕玲,王忠,高峰,雒猛）
  • 收稿日期:2021-12-21 出版日期:2022-06-20 发布日期:2022-06-22
  • 通讯作者: 雒猛,男,主要从事脐带血临床应用研究,（E-mail）17615835493@163.com。
  • 作者简介:邢义高（1993-）,男,山东济南人,硕士,主要从事脐带血干细胞临床应用研究,（E-mail）2890157516@qq.com。

Analysis of the Influence of Maternal and Infant Factors on the Quality Parameters of Umbilical Cord Blood Based on Multiple Linear Regression

XING Yi-gao, ZHANG Xiu-tao, LV Ling, et al   

  1. Cell and Tissue Bank of Shandong, Cord Blood Hematopoietic Stem Cell Bank of Shandong, Qilu Stem Cell Engineering Company Ltd of Shandong, Jinan 250102
  • Received:2021-12-21 Online:2022-06-20 Published:2022-06-22

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摘要： 目的 探讨母婴因素对脐带血有核细胞总数（total nucleated cell,TNC）和CD34+细胞数量的预测意义。方法 对山东省脐带血造血干细胞库8 267份公共库脐带血的产妇年龄、孕周、脐血体积、分娩方式、新生儿性别、血型等信息进行统计,以Spearman秩相关性分析为基础,结合多元线性回归分析研究了不同母婴因素对TNC、CD34+细胞数量的影响。结果 产妇年龄、新生儿血型与TNC和CD34+细胞数量均无显著相关性;孕周、脐血体积、分娩方式、新生儿性别与TNC和CD34+细胞数量均具有显著相关性,其中,分娩方式对TNC的影响最大,顺产的TNC高于剖宫产;新生儿性别对CD34+细胞数量的影响最大,男孩脐血中的CD34+细胞数量要高于女孩。结论 通过分析母婴因素对脐血质量参数的影响和多元线性回归模型的建立,可有效预测脐带血中TNC和CD34+细胞的数量。

关键词: 脐带血, 有核细胞总数, CD34+细胞数量, 母婴因素

Abstract: Objective To explore the predictive significance of maternal and infant factors on the total number of nucleated cells （TNC） and CD34+ cells in umbilical cord blood. Methods Conducting statistical analysis on the maternal age, the gestational age, the volume of umbilical cord blood, the delivery method, the gender and the blood type of neonates, and other information of the 8 267 samples collected from the Shandong cord blood hematopoietic stem cell bank. The effects of different maternal and infant factors on the number of TNC and CD34+ cells were studied, based on Spearman rank correlation analysis, combined with multiple linear regression. Results There was no significant correlation between the maternal age, the blood type of neonates and the quantity of TNC and CD34+ cells. The gender of neonates, the mode of delivery, the gestational age, and the volume of the cord blood were all significantly correlated with the quantity of TNC and CD34+ cells. The mode of delivery had the greatest effect on TNC, and the TNC of normal delivery is greater than that of cesarean section. The gender of neonates had the greatest effect on CD34+ cells, and the quantity of CD34+ cells in boys was bigger than in girls. Conclusion By analyzing the influence of maternal and infant factors on cord blood quality parameters and establishing a multiple linear regression model, the number of TNC and CD34+ cells in cord blood can be effectively predicted.

Key words: Umbilical cord blood, Total nucleated cell, CD34+ cell number, Maternal and infant factors

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