[1] VALLELIAN F,BUEHLER P W,SCHAER D J.Hemolysis,free hemoglobin toxicity,and scavenger protein therapeutics[J].Blood,2022,140(17):1837-1844. [2] 卫新,王耀美,曲晓利,等.游离血红素病理相关研究进展[J].国际输血及血液学杂志,2019,42(3):254-258. [3] VISSA M,LARKIN S K,VICHINSKY E P,et al.Assessment of total and unbound cell-free heme in plasma of patients with sickle cell disease[J].Exp Biol Med (Maywood),2023:153537022311579. [4] DEY S,BINDU S,GOYAL M,et al.Impact of intravascular hemolysis in malaria on liver dysfunction:involvement of hepatic free heme overload,NF-κB activation,and neutrophil infiltration[J].J Biol Chem,2012,287(32):26630-26646. [5] VINCHI F,COSTA DA SILVA M,INGOGLIA G,et al.Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease[J].Blood,2016,127(4):473-486. [6] BELCHER J D,CHEN C S,NGUYEN J,et al.Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease[J].Blood,2014,123(3):377-390. [7] DUTT S,HAMZA I,BARTNIKAS T B.Molecular mechanisms of iron and heme metabolism[J].Annu Rev Nutr,2022,42:311-335. [8] NOCENTINI A,BONARDI A,PRATESI S,et al.Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin[J].J Enzyme Inhib Med Chem,2022,37(1):487-501. [9] SALGAR S,BOLÍVAR B E,FLANAGAN J M,et al.The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions[J].Transl Res,2023,252:34-44. [10] VAN WIJK K,AKABANE T,KIMURA T,et al.Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme,but not total heme,in skeletal muscle and liver[J].Arch Biochem Biophys,2021,697:108721. [11] 徐薇,彭芳,李宁.红细胞衰亡及其在肝脏中的识别与清除机制[J].生命科学研究,2019,23(2):135-139. [12] GBOTOSHO O T,KAPETANAKI M G,KATO G J.The worst things in life are free:the role of free heme in sickle cell disease[J].Front Immunol,2021,11:561917. [13] XU F, PENG Y, XIE H, et al.A multicenter study on the quantification of liver iron concentration in thalassemia patients by means of the MRI T2* technique[J].Front Med (Lausanne),2023,10:1180614. [14] TOWERMAN A S, GUILLIAMS K P, GUERRIERO R, et al.Hyperammonemia and acute liver failure associated with deferasirox in two adolescents with sickle cell disease[J].Br J Haematol, 2023, 201(4): e30-e33. [15] 刘志新,吴晓双,孟炜程,等.一种急性溶血性输血反应小鼠动物模型的建立[J].临床输血与检验,2023,25(1):63-69. [16] AICH A,FREUNDLICH M,VEKILOV P G.The free heme concentration in healthy human erythrocytes[J].Blood Cells Mol Dis,2015,55(4):402-409. [17] 何晓莉,苗辉.AST、ALT与γ-GT检验在肝硬化患者中的应用价值分析[J].数理医药学杂志,2021,34(11):1718-1720. [18] SHIN J H,KIM K,NAM H J.Influence of combined therapy with conventional and herbal medicines on liver function in 138 inpatients with abnormal liver transaminase levels[J].BMC Complement Altern Med,2016,16(1):496. [19] KAUR P,NAGAR S,BHAGWAT M,et al.Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells[J].PLoS One,2021,16(11):e0260400. |