石墨烯及其衍生物在骨组织工程中的研究进展

doi:10.3969/j.issn.1671-2587.2024.01.022

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (1): 136-144.DOI: 10.3969/j.issn.1671-2587.2024.01.022

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石墨烯及其衍生物在骨组织工程中的研究进展

常新代^1,2, 孙苏静², 彭东新², 王小慧², 张振琳¹

¹燕山大学亚稳材料制备技术与科学国家重点实验室,材料科学与工程学院,河北秦皇岛 066004;
²军事科学院军事医学研究院卫生勤务与血液研究所,北京 100850

收稿日期:2023-12-22 发布日期:2024-03-13
通讯作者: 张振琳,主要从事智能响应高分子材料方面研究, （E-mail）leafzzl@163. com。共同通信作者：王小慧,主要从事输血安全与纳米生物技术研究,（E-mail）lovechina1980@163.com。
作者简介:常新代,主要从事纳米生物学方面研究,（E-mail）cxd1249759140@163.com。

Advances in Graphene and Its Derivatives in Bone Tissue Engineering

CHANG Xindai^1,2, SUN Sujing², PENG Dongxin², WANG Xiaohui², ZHANG Zhenlin¹

¹State Key Laboratory of Metastable Materials Science and Technology, School of Materials Science and Engineering, Yanshan University, Qinhuangdao 066004;
²Institute of Health Service and Transfusion Medicine,Academy of Military Medical Sciences,Academy of Military Sciences, Beijing 100850

Received:2023-12-22 Published:2024-03-13

摘要/Abstract

摘要： 近年来,纳米材料在骨组织工程材料的应用中显示出独特的优势。石墨烯及其衍生物如氧化石墨烯,还原氧化石墨烯作为代表性的二维纳米材料,具有优异的机械性能、大的比表面积、良好的导电性能和生物相容性,被认为具有巨大的骨组织工程应用潜力。在此,本文回顾了石墨烯及其衍生物作为新型复合骨工程支架的增强组分和药物载体的应用,介绍了基于不同动物模型的应用研究,以便充分验证石墨烯及其衍生物的诱骨效应;对成骨分化相关信号通路如Wnt/β-catenin信号通路,MAPK信号通路以及BMP信号通路各自发挥的作用及各条通路之间的相互关系进行了梳理,对阐明成骨分化调控机制具有重要意义。

关键词: 石墨烯及其衍生物, 间充质干细胞, 成骨分化, 骨组织工程

Abstract: In recent years, nanomaterials have shown unique advantages in the application of bone tissue engineering materials. Graphene and its derivatives such as graphene oxide, reduced graphene oxide, as representative two-dimensional nanomaterials with excellent mechanical properties, large specific surface area, good electrical conductivity and biocompatibility, are considered to have great potential for bone tissue engineering applications. Herein, the applications of graphene and its derivatives as reinforcement components and drug carriers for novel composite bone engineering scaffolds are reviewed, and application studies based on different animal models are also presented in order to fully validate the osteoinductive effects of graphene and its derivatives. Subsequently, the signalling pathways related to osteogenic differentiation, such as Wnt, MAPK and BMP, were summarized, and their respective roles and the interrelationships among these pathways were clarified, which is of great significance for the elucidation of the regulatory mechanism of osteogenic differentiation.

Key words: Graphene and its derivatives, Mesenchymal stem cells, Osteogenic differentiation, Bone tissue engineering

中图分类号:

R318.08

常新代, 孙苏静, 彭东新, 王小慧, 张振琳. 石墨烯及其衍生物在骨组织工程中的研究进展[J]. 临床输血与检验, 2024, 26(1): 136-144.

CHANG Xindai, SUN Sujing, PENG Dongxin, WANG Xiaohui, ZHANG Zhenlin. Advances in Graphene and Its Derivatives in Bone Tissue Engineering[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(1): 136-144.

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石墨烯及其衍生物在骨组织工程中的研究进展

Advances in Graphene and Its Derivatives in Bone Tissue Engineering

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