液体血浆在战伤急救中的应用与展望*

doi:10.3969/j.issn.1671-2587.2025.05.012

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (5): 662-666.DOI: 10.3969/j.issn.1671-2587.2025.05.012

液体血浆在战伤急救中的应用与展望^*

张婧, 尹文

空军军医大学西京医院输血科,陕西西安 710032

收稿日期:2025-09-06 修回日期:2025-09-11 出版日期:2025-10-20 发布日期:2025-10-11
通讯作者: 尹文,主要从事输血医学研究,（E-mail）yinwen@fmmu.edu.cn。
作者简介:张婧,主要从事输血医学研究,（E-mail）zjsworld8926@163.com。
基金资助:
^*本课题受西京医院医务人员培养助推项目（No.XJZT24CY44）资助

The Application and Prospect of Liquid Plasma in Emergency Treatment of Military Trauma

ZHANG Jing, YIN Wen

Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032

Received:2025-09-06 Revised:2025-09-11 Online:2025-10-20 Published:2025-10-11

摘要/Abstract

摘要： 随着高新武器的应用,现代战争战伤伤情具有严重性和复杂性。急性失血性休克是伤员死亡的主要原因之一,尽早进行液体复苏对提高生存率具有重要意义。液体血浆（liquid plasma, LP）具有制备工艺简单、输血准备时间短、运输和储存过程对冷链依赖性低等特点,有利于保障患者在抢救黄金时间内及时有效的液体复苏。不同于冰冻血浆和冻干血浆,LP具有适应于战伤救治的独特特点和自身优势,为其作为血液保障体系的一部分提供了先决条件。本文对比了LP和其他血浆制品的特征,并对其在战伤急救的优劣势、应用现状和前景进行分析,为其在军事领域的进一步应用及发展提供参考。

关键词: 液体血浆, 液体复苏, 战伤急救

Abstract: With the application of advanced weapons, the traumatic condition in modern warfare has become severe and complex. Acute hemorrhagic shock is the leading cause of death among patients. Early fluid resuscitation is of great significance for improving the survival rate. Liquid plasma (LP) has the characteristics of simple preparation process, short blood transfusion preparation time, and low dependence on cold chain during transportation and storage, which is conducive to ensuring timely and effective fluid resuscitation for patients within the golden time of rescue. Different from the frozen plasma and freeze-dried plasma, LP has unique characteristics and its own advantages that are suitable for the treatment of war wounds, providing a prerequisite for it to be part of the blood support system. This article compares the characteristics of LP and other plasma products, and analyzes its advantages and disadvantages, application status and prospects as emergency resuscitation fluid for war wounds, providing information for its further application and development in the military field.

Key words: Liquid plasma, Fluid resuscitation, Emergency treatment of military trauma

中图分类号:

R459.7R457.1⁺4

张婧, 尹文. 液体血浆在战伤急救中的应用与展望^*[J]. 临床输血与检验, 2025, 27(5): 662-666.

ZHANG Jing, YIN Wen. The Application and Prospect of Liquid Plasma in Emergency Treatment of Military Trauma[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 662-666.

参考文献

[1] ROSSAINT R,AFSHARI A,BOUILLON B,et al.The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition[J]. Crit Care,2023,27(1):80.
[2] NASSER A A H,NEDERPELT C,EL HECHI M,et al. Every minute counts: The impact of pre-hospital response time and scene time on mortality of penetrating trauma patients[J]. Am J Surg,2020,220(1):240-244.
[3] DEATON T G,DREW B,MONTGOMERY H R,et al.Tactical combat casualty care (TCCC) guidelines: 25 January 2024[J]. J Spec Oper Med,2024,24(1):100-108.
[4] 杨成民, 刘进, 赵桐茂, 等. 中华输血学 2版[M]. 北京:人民卫生出版社, 2021: 366-367.
[5] CLAUDIA SC, MEGHAN D, SUSAN TJ,等. AABB技术手册[M].20版,桂嵘,等主译.长沙:中南大学出版社,2022: 109.
[6] RAPAILLE A,LOTENS A,DE VALENSART N,et al.Evaluation of the hemostatic capacity of methylene blue-treated liquid (not frozen) plasma stored up 14 days at 2° to 6 ℃[J]. Transfusion,2021,61(8):2450-2457.
[7] MELEDEO M A,PELTIER G C,MCINTOSH C S,et al.Coagulation function of never frozen liquid plasma stored for 40 days[J]. Transfusion,2021,61(Suppl 1): S111-S118.
[8] FADEYI E A,SAHA A K,SOLTANI S,et al.A comparison between liquid group A plasma and thawed group A plasma for massive transfusion activation in trauma patients[J]. Vox Sang,2022,117(4):513-519.
[9] BEATTIE G,COHAN C M,NG V L,et al.Liquid plasma: A solution to optimizing early and balanced plasma resuscitation in massive transfusion[J]. J Trauma Acute Care Surg,2020,89(3):488-495.
[10] CHEHAB M,DITILLO M,OBAID O,et al.Never-frozen liquid plasma transfusion in civilian trauma: a nationwide propensity-matched analysis[J]. J Trauma Acute Care Surg,2021,91(1):200-205.
[11] CONNOR J P,JALADI S,CAO W J,et al.Expanded use of liquid plasma in non-emergency transfusions: A single academic institution experience[J]. Transfusion, 2025,65(3):466-475.
[12] 陆红祥,古丽努尔·库尔班,文爱清. 冻干血浆在战创伤失血性休克救治中的应用研究进展[J]. 创伤外科杂志, 2022,24(2):96-99.
[13] PENG H T,SINGH K,RHIND S G,et al.Dried plasma for major trauma: past,present,and future[J]. Life,2024, 14(5):619.
[14] PUSATERI A E,KISHMAN A J,ARIFFIN M A B,et al. Potential military applications for a new freeze-dried plasma[J]. Transfusion,2025,65(S1):S240-S249.
[15] CARDIGAN R,GREEN L.Thawed and liquid plasma—what do we know?[J]. Vox Sang,2015,109(1):1-10.
[16] HALL A B,QURESHI I,MCMINN H,et al.US Central Command military blood utilization practices 2011 to 2020[J]. J Trauma Acute Care Surg,2022,93(2S Suppl 1): S30-S34.
[17] CLARKE E E,HAMM J,FISHER A D,et al.Trends in prehospital blood,crystalloid,and colloid administration in accordance with changes in tactical combat casualty care guidelines[J]. Mil Med,2022,187(11/12):e1265-e1270.
[18] RAJESH A,SCHAEFER R M,KROHMER J R, et al.From shortages to solutions: Liquid plasma as a practical alternative to whole blood for prehospital trauma resuscitation[J]. Transfusion,2025,65(Suppl 1): S288-S296.

液体血浆在战伤急救中的应用与展望^*

The Application and Prospect of Liquid Plasma in Emergency Treatment of Military Trauma

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价

关于本刊

作者中心

在线期刊

访问统计

联系我们