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临床输血与检验

临床输血与检验 ›› 2026, Vol. 28 ›› Issue (1): 141-145.DOI: 10.3969/j.issn.1671-2587.2026.01.022

• 临床检验 • 上一篇    下一篇

血清PAD2、NF-κB、HBP水平与肺部感染相关性的研究*

关向前, 王东升, 孙安源   

  1. 中国科学技术大学附属第一医院（安徽省立医院）检验科，安徽合肥 230001
  • 收稿日期:2025-10-11 发布日期:2026-02-13
  • 通讯作者: 孙安源，主要从事临床免疫学研究，（E-mail）3148620263@qq.com。
  • 作者简介:关向前，主要从事免疫学检验研究，（E-mail）gxq466216@163.com。
  • 基金资助:
    *本项目受2024年安徽省卫生健康科研项目（No.AHWJ2024 Aa20568）资助

The Study for Correlation between Serum PAD2, NF-κB, HBP and Pulmonary Infection

GUAN Xiangqian, WANG Dongsheng, SUN Anyuan   

  1. Department of Laboratory Medicine, First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001
  • Received:2025-10-11 Published:2026-02-13

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摘要： 目的 探讨血清肽基精氨酸脱亚胺酶（PAD）2、核因子-κB（NF-κB）、肝素结合蛋白（HBP）水平与肺部感染的关系，以及三者联合检测对肺部感染的诊断价值。方法 选择2020年1月1日—2025年1月30日中国科学技术大学附属第一医院收治的肺部感染患者84例（观察组），选择30例同期无感染患者作为对照组。酶联免疫吸附试验（ELISA）法检测血清PAD2、NF-κB水平;免疫荧光法检测HBP水平;Pearson's correlation法分析血清PAD2、NF-κB、HBP与白细胞计数（WBC），中性粒细胞占比及C-反应蛋白的相关性;Logistic回归分析肺部感染的危险因素;ROC曲线分析血清PAD2、NF-κB、HBP对肺部感染的诊断效能。结果 观察组患者血清PAD2、NF-κB、HBP水平均显著高于对照组（P<0.05）。PAD2、NF-κB、HBP三者水平与白细胞计数，中性粒细胞占比及C-反应蛋白呈显著正相关性（P<0.05）。血清PAD2、NF-κB、HBP水平升高是影响肺部感染的危险因素（P<0.05）。血清PAD2、NF-κB、HBP及其联合诊断肺部感染的ROC曲线下面积分别为0.814、0.787、0.804、0.930，联合检测诊断效能更佳（Z三者联合=3.226，P<0.05）。结论 肺部感染患者血清PAD2、NF-κB、HBP水平与感染关系密切，且指标高低与白细胞计数，中性粒细胞占比及C-反应蛋白水平正相关，三者联合检测对于肺部感染具有较好的诊断价值。

关键词: 肺部感染, 肽基精氨酸脱亚胺酶2, 核因子-κB, 肝素结合蛋白

Abstract: Objective To explore the relationship between serum levels of peptidylarginine deiminase (PAD) 2, nuclear factor-kappa B (NF-κB), heparin binding protein (HBP) and pulmonary infections, and the diagnosis value of their combined detection for pulmonary infections. Methods From 1 January 2020 to 30 January 2025, 84 patients with pulmonary infections in our hospital were recruited, and 30 non-infected hospitalized patients were set as control group. ELISA method was used to detect serum levels of PAD2 and NF-κB, and HBP level were detected by immunofluorescence. Pearson's correlation method was used to analyze the correlation between serum PAD2, NF-κB, HBP and white blood cell count (WBC), C-reactive protein, neutrophil percentage.. Logistic regression was used to analyze the influencing factors of lung infection. ROC curve was used to evaluate the usefulness of serum PAD2, NF-κB, and HBP for diagnosis of pulmonary infections. Results The serum levels of PAD2, NF-κB, and HBP of patients in the observation group were significantly higher than those in the control group (P<0.05). The serum levels of PAD2, NF-κB, HBP significantly correlated with the levels of white blood cell count (WBC), C-reactive protein and neutrophil percentage in observation group (P<0.05). Serum PAD2, NF-κB, and HBP were risk factors for pulmonary infection (P<0.05). The areas under the curve (AUC) of ROC of PAD2, NF-κB, HBP and combination for diagnosis of pulmonary infection were 0.814, 0.787, 0.804, and 0.930 respectively, and the diagnostic efficacy of the combined test was better (Zcombination=3.226, P<0.05). Conclusion Serum levels of PAD2, NF-κB, and HBP were closely related to pulmonary infections, and correlated with the levels of infection indicators, and the combination of these three factors displays a better diagnostic value for pulmonary infection.

Key words: Pulmonary infection, Peptidylarginine deiminase 2, Nuclear factor-kappa B, Heparin binding protein

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