银杏内酯B调控血小板活化分子机制的研究进展*

doi:10.3969/j.issn.1671-2587.2026.01.023

临床输血与检验 ›› 2026, Vol. 28 ›› Issue (1): 146-152.DOI: 10.3969/j.issn.1671-2587.2026.01.023

• 综述 • 上一篇

银杏内酯B调控血小板活化分子机制的研究进展^*

何盈, 冯文秋, 秦萍, 朱培元

南京中医药大学附属南京中医院，江苏南京 210022

收稿日期:2025-07-14 发布日期:2026-02-13
通讯作者: 朱培元，主要从事临床输血研究，（E-mail）zhupy@njucm.edu.cn。
作者简介:何盈，主要从事中西医结合肛肠外科及输血研究，（E-mail）381186788@qq.com。
基金资助:
*本课题受国家重点研发计划“中医药现代化”重点专项子课题（No.2025YFC3507504）、南京中医药大学中医药防治高原应激项目（No.ZYYFZGYYJ02）资助

Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation

HE Ying, FENG Wenqiu, QIN Ping, ZHU Peiyuan

Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022

Received:2025-07-14 Published:2026-02-13

摘要/Abstract

摘要： 银杏内酯B（ginkgolide B, GB）为中药银杏叶中提取的典型二萜内酯类活性成分，具有高效拮抗血小板活化因子（platelet-activating factor, PAF）的作用，可以抑制血小板活化、抗氧化、对抗血栓形成以及保护血管等，尤其在调控血小板活化功能方面展示出良好的应用前景。机制上，GB可通过多条信号通路发挥作用，包括Ca²⁺信号通路、PI3K信号通路、花生四烯酸（arachidonic acid, AA）代谢通路及整合素αⅡbβ3介导的信号通路，从而发挥调控血小板活化功能。

关键词: 银杏内酯B, 血小板功能, 信号通路, 血小板活化

Abstract: Ginkgolide B is a typical diterpene lactone active ingredient extracted from the traditional Chinese medicine Ginkgo biloba, which has the effect of efficiently antagonizing platelet-activating factor, and can be involved in the inhibition of platelet activation, antioxidant, anti-thrombosis, and protection of blood vessels, especially in the regulation of platelet function demonstrates a good prospect of application. Mechanistically, GB can exert its effects through multiple signaling pathways, including Ca²⁺ signaling pathway, phosphatidylinositol 3-kinase signaling axis, arachidonic acid metabolic pathway and integrin αⅡbβ3-mediated signaling pathway, so as to exert the effect of platelet function regulation.

Key words: Ginkgolide B, Platelet function, Signaling pathway, platelet activation

中图分类号:

R285.5R446.1

何盈, 冯文秋, 秦萍, 朱培元. 银杏内酯B调控血小板活化分子机制的研究进展^*[J]. 临床输血与检验, 2026, 28(1): 146-152.

HE Ying, FENG Wenqiu, QIN Ping, ZHU Peiyuan. Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(1): 146-152.

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银杏内酯B调控血小板活化分子机制的研究进展^*

Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation

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