- 中国科学论文统计源期刊
- 中国科技核心期刊
- 美国化学文摘(CA)来源期刊
- 日本科学技术振兴机构数据库(JST)
临床输血与检验 ›› 2022, Vol. 24 ›› Issue (3): 392-398.DOI: 10.3969/j.issn.1671-2587.2022.03.023
苏贤, 李艳宏, 阎少多
收稿日期:2022-01-26
出版日期:2022-06-20
发布日期:2022-06-22
通讯作者:
阎少多,男,副研究员,硕士生导师,博士,血细胞储存与血小板清除机制,（E-mail）ysd-dtc@163.com。
作者简介:苏贤（1998-）,女,四川攀枝花人,硕士,（E-mail）2279615114@qq.com。
基金资助:
Received:2022-01-26
Online:2022-06-20
Published:2022-06-22
摘要： 肝脏具有强大的再生能力,肝切除术或肝移植术的成功,主要取决于术后肝脏能否恢复正常的生理功能和体积。研究表明,血小板在促进肝再生中发挥着重要作用。然而,其作用机制尚未完全明确。本文就血小板促进肝再生的作用机制及其研究进展作一综述,以期为肝切除或肝移植相关术后肝再生提供新的治疗策略。
中图分类号:
苏贤, 李艳宏, 阎少多. 血小板促进肝再生的作用机制及其研究进展*[J]. 临床输血与检验, 2022, 24(3): 392-398.
| [1] MICHALOPOULOS G K ",BHUSHAN B. Liver regeneration:biological and pathological mechanisms and implications[J]. Nat Rev Gastroenterol Hepatol,2021,18(1):40-55. [2] WEI Y L,WANG Y,JIA Y M,et al. Liver homeostasis is maintained by midlobular zone 2 hepatocytes[J]. Science,2021,371(6532):eabb1625. [3] HE L J,PU W J,LIU X X,et al. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair[J]. Science,2021,371(6532):eabc4346. [4] DEANGELIS R A,KOVALOVICH K,CRESSMAN D E,et al.Normal liver regeneration in p50/nuclear factor kappaB1 knockout mice[J]. Hepatology,2001,33(4):915-924. [5] STREETZ K L,LUEDDE T,MANNS M P,et al.Interleukin 6 and liver regeneration[J]. Gut,2000,47(2):309-312. [6] 曾宪飞,胡兴斌. 血小板诱导肝再生的研究进展[J]. 中国输血杂志,2018,31(10):1205-1208. [7] MURATA S,MARUYAMA T,NOWATARI T,et al.Signal transduction of platelet-induced liver regeneration and decrease of liver fibrosis[J]. Int J Mol Sci,2014,15(4):5412-5425. [8] IANNACONE M.Platelet-mediated modulation of adaptive immunity[J]. Semin Immunol,2016,28(6):555-560. [9] TSUKIJI N,INOUE O,MORIMOTO M,et al.Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction[J]. Blood,2018,132(11):1167-1179. [10] XIANG B G,ZHANG G Y,GUO L,et al.Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway[J]. Nat Commun,2013,4:2657. [11] KANIKARLA MARIE P,FOWLKES N W,AFSHAR-KHARGHAN V,et al.The provocative roles of platelets in liver disease and cancer[J]. Front Oncol,2021,11:643815. [12] PAUL D,PIASECKI A.Rat platelets contain growth factor(s) distinct from PDGF which stimulate DNA synthesis in primary adult rat hepatocyte cultures[J]. Exp Cell Res,1984,154(1):95-100. [13] MATSUO R,OHKOHCHI N,MURATA S,et al.Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro[J]. J Surg Res,2008,145(2):279-286. [14] STARLINGER P,HAEGELE S,OFFENSPERGER F,et al.The profile of platelet α-granule released molecules affects postoperative liver regeneration[J]. Hepatology,2016,63(5):1675-1688. [15] NAKAMURA T.Cell growth inhibitors and TGF-beta masking protein in platelets[J]. Seikagaku,1987,59(3):147-153. [16] HISAKURA K,MURATA S,FUKUNAGA K,et al.Platelets prevent acute liver damage after extended hepatectomy in pigs[J]. J Hepatobiliary Pancreat Sci,2010,17(6):855-864. [17] MURATA S,OHKOHCHI N,MATSUO R,et al.Platelets promote liver regeneration in early period after hepatectomy in mice[J]. World J Surg,2007,31(4):808-816. [18] MURATA S,MATSUO R,IKEDA O,et al.Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice[J]. World J Surg,2008,32(6):1088-1096. [19] MURATA S,HASHIMOTO I,NAKANO Y,et al.Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats[J]. Ann Surg,2008,248(5):821-828. [20] MATSUO R,NAKANO Y,OHKOHCHI N.Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy[J]. Ann Surg,2011,253(4):759-763. [21] TAKAHASHI K,KOZUMA Y,SUZUKI H,et al.Human platelets promote liver regeneration with Kupffer cells in SCID mice[J]. J Surg Res,2013,180(1):62-72. [22] MYRONOVYCH A,MURATA S,CHIBA M,et al.Role of platelets on liver regeneration after 90% hepatectomy in mice[J]. J Hepatol,2008,49(3):363-372. [23] LÓPEZ M L,KIELING C O,URIBE CRUZ C,et al. Platelet increases survival in a model of 90% hepatectomy in rats[J]. Liver Int,2014,34(7):1049-1056. [24] LIANG C,TAKAHASHI K,FURUYA K,et al.Platelets stimulate liver regeneration in a rat model of partial liver transplantation[J]. Liver Transpl,2021,27(5):719-734. [25] WANG H Q,YANG J,YANG J Y,et al.Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy[J]. World J Gastroenterol,2014,20(33):11871-11877. [26] MEHRABI A,GOLRIZ M,KHAJEH E,et al.Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality[J]. Br J Surg,2018,105(10):1254-1261. [27] ALKOZAI E M,NIJSTEN M W,DE JONG K P,et al. Immediate postoperative low platelet count is associated with delayed liver function recovery after partial liver resection[J]. Ann Surg,2010,251(2):300-306. [28] LESURTEL M,RAPTIS D A,MELLOUL E,et al.Low platelet counts after liver transplantation predict early posttransplant survival:the 60-5 criterion[J]. Liver Transpl,2014,20(2):147-155. [29] MARGONIS G A,AMINI N,BUETTNER S,et al.Impact of early postoperative platelet count on volumetric liver gain and perioperative outcomes after major liver resection[J]. Br J Surg,2016,103(7):899-907. [30] HAN S B,PARK H W,SONG J H,et al.Association between intraoperative platelet transfusion and early graft regeneration in living donor liver transplantation[J]. Ann Surg,2016,264(6):1065-1072. [31] NAKAMURA M,SHIBAZAKI M,NITTA Y,et al.Translocation of platelets into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides,interleukin-1 and tumour necrosis factor:the role of Kupffer cells[J]. J Hepatol,1998,28(6):991-999. [32] LANG P A,CONTALDO C,GEORGIEV P,et al.Aggravation of viral hepatitis by platelet-derived serotonin[J]. Nat Med,2008,14(7):756-761. [33] MEYER J,LEJMI E,FONTANA P,et al.A focus on the role of platelets in liver regeneration:do platelet-endothelial cell interactions initiate the regenerative process?[J]. J Hepatol,2015,63(5):1263-1271. [34] ENDO Y,NAKAMURA M.The effect of lipopolysaccharide,interleukin-1 and tumour necrosis factor on the hepatic accumulation of 5-hydroxytryptamine and platelets in the mouse[J]. Br J Pharmacol,1992,105(3):613-619. [35] GROENEVELD D,PEREYRA D,VELDHUIS Z,et al.Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans[J]. Blood,2019,133(11):1245-1256. [36] GROZOVSKY R,BEGONJA A J,LIU K,et al.The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling[J]. Nat Med,2015,21(1):47-54. [37] GROZOVSKY R,BEGONJA A J,LIU K F,et al.The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling[J]. Nat Med,2015,21(1):47-54. [38] MEYER J,BALAPHAS A,FONTANA P,et al.Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation[J]. Cells,2020,9(5):1243. [39] KONO H,FUJII H,SUZUKI-INOUE K,et al.The platelet-activating receptor C-type lectin receptor-2 plays an essential role in liver regeneration after partial hepatectomy in mice[J]. J Thromb Haemost,2017,15(5):998-1008. [40] KAWASAKI T,MURATA S,TAKAHASHI K,et al.Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation[J]. J Hepatol,2010,53(4):648-654. [41] NOWATARI T,MURATA S,NAKAYAMA K,et al.Sphingosine 1-phosphate has anti-apoptotic effect on liver sinusoidal endothelial cells and proliferative effect on hepatocytes in a paracrine manner in human[J]. Hepatol Res,2015,45(11):1136-1145. [42] BALAPHAS A,MEYER J,PEROZZO R,et al.Platelet transforming growth factor-β1 induces liver sinusoidal endothelial cells to secrete interleukin-6[J]. Cells,2020,9(5):1311. [43] GRANADO M,MARTÍN A I,PRIEGO T,et al. Inactivation of Kupffer cells by gadolinium administration prevents lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression[J]. J Endocrinol,2006,188(3):503-511. [44] ABSHAGEN K,EIPEL C,KALFF J C,et al.Loss of NF-kappaB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy[J]. Am J Physiol Gastrointest Liver Physiol,2007,292(6):G1570-G1577. [45] TAKAHASHI K,MURATA S,OHKOHCHI N.Novel therapy for liver regeneration by increasing the number of platelets[J]. Surg Today,2013,43(10):1081-1087. [46] LÓPEZ M L,URIBE-CRUZ C,OSVALDT A,et al. Encapsulated platelets modulate kupffer cell activation and reduce oxidative stress in a model of acute liver failure[J]. Liver Transpl,2016,22(11):1562-1572. [47] FAUSTO N,LAIRD A D,WEBBER E M.Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration[J]. FASEB J,1995,9(15):1527-1536. [48] OZAKI M.Role of jak/STAT3 and PI3-K/Akt pathways in liver injury and regeneration[J]. Seikagaku,2008,80(5):399-408. [49] TAKAHASHI K,LIANG C,ODA T,et al.Platelet and liver regeneration after liver surgery[J]. Surg Today,2020,50(9):974-983. [50] TULASNE D,FOVEAU B.The shadow of death on the MET tyrosine kinase receptor[J]. Cell Death Differ,2008,15(3):427-434. [51] HAGA S,OGAWA W,INOUE H,et al.Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice[J]. J Hepatol,2005,43(5):799-807. [52] KIRSCHBAUM M,JENNE C N,VELDHUIS Z J,et al.Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice[J]. Liver Int,2017,37(11):1731-1737. [53] AWUAH P K,NEJAK-BOWEN K N,MONGA S P S. Role and regulation of PDGFRα signaling in liver development and regeneration[J]. Am J Pathol,2013,182(5):1648-1658. [54] KIKUCHI A,MONGA S P.PDGFRα in liver pathophysiology:emerging roles in development,regeneration,fibrosis,and cancer[J]. Gene Expr,2015,16(3):109-127. [55] PEARSON G,ROBINSON F,BEERS GIBSON T,et al.Mitogen-activated protein (MAP) kinase pathways:regulation and physiological functions[J]. Endocr Rev,2001,22(2):153-183. [56] GAO B,WANG H,LAFDIL F,et al.STAT proteins - key regulators of anti-viral responses,inflammation,and tumorigenesis in the liver[J]. J Hepatol,2012,57(2):430-441. [57] HAGA S,OZAKI M,INOUE H,et al.The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation[J]. Hepatology,2009,49(1):204-214. [58] CRESSMAN D E,GREENBAUM L E,DEANGELIS R A,et al.Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice[J]. Science,1996,274(5291):1379-1383. [59] SUDO K,YAMADA Y,SAITO K,et al.TNF-alpha and IL-6 signals from the bone marrow derived cells are necessary for normal murine liver regeneration[J]. Biochim Biophys Acta,2008,1782(11):671-679. [60] SCHMIDT-ARRAS D,ROSE-JOHN S.IL-6 pathway in the liver:from physiopathology to therapy[J]. J Hepatol,2016,64(6):1403-1415. [61] FAZEL MODARES N,POLZ R,HAGHIGHI F,et al.IL-6 trans-signaling controls liver regeneration after partial hepatectomy[J]. Hepatology,2019,70(6):2075-2091. [62] NECHEMIA-ARBELY Y,SHRIKI A,DENZ U,et al.Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation[J]. J Hepatol,2011,54(5):922-929. [63] KALDENBACH M,GIEBELER A,TSCHAHARGANEH D F,et al.Hepatocyte growth factor/c-Met signalling is important for the selection of transplanted hepatocytes[J]. Gut,2012,61(8):1209-1218. [64] QIAN J J,LIU J P,HONG L J,et al.Upregulation of PDGF mediates robust liver regeneration after nanosecond pulsed electric field ablation by promoting the HGF/c-met pathway[J]. Biomed Res Int,2020,2020:3635787. [65] ISHIKAWA T,FACTOR V M,MARQUARDT J U,et al.Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice[J]. Hepatology,2012,55(4):1215-1226. [66] HINZ M,KRAPPMANN D,EICHTEN A,et al.NF-kappaB function in growth control:regulation of cyclin D1 expression and G0/G1-to-S-phase transition[J]. Mol Cell Biol,1999,19(4):2690-2698. [67] YANG L,MAGNESS S T,BATALLER R,et al.NF-kappaB activation in Kupffer cells after partial hepatectomy[J]. Am J Physiol Gastrointest Liver Physiol,2005,289(3):G530-G538. [68] MICHALOPOULOS G K,DEFRANCES M.Liver regeneration[J]. Adv Biochem Eng Biotechnol,2005,93:101-134. [69] DEVI S S,MEHENDALE H M.The role of NF-kappaB signaling in impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats[J]. Eur J Pharmacol,2005,523(1/2/3):127-136. [70] YAMADA Y,WEBBER E M,KIRILLOVA I,et al.Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor:requirement for type 1 but not type 2 receptor[J]. Hepatology,1998,28(4):959-970. [71] YAMADA Y,KIRILLOVA I,PESCHON J J,et al.Initiation of liver growth by tumor necrosis factor:deficient liver regeneration in mice lacking type I tumor necrosis factor receptor[J]. Proc Natl Acad Sci USA,1997,94(4):1441-1446. [72] PLÜMPE J,MALEK N P,BOCK C T,et al. NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration[J]. Am J Physiol Gastrointest Liver Physiol,2000,278(1):G173-G183. [73] STARLINGER P,ASSINGER A,HAEGELE S,et al.Evidence for serotonin as a relevant inducer of liver regeneration after liver resection in humans[J]. Hepatology,2014,60(1):257-266. [74] ALKOZAI E M,VAN FAASSEN M,KEMA I P,et al.Evidence against a role of serotonin in liver regeneration in humans[J]. Hepatology,2015,62(3):983. [75] LESURTEL M,GRAF R,ALEIL B,et al.Platelet-derived serotonin mediates liver regeneration[J]. Science,2006,312(5770):104-107. [76] TIAN Y H,GRAF R,EL-BADRY A M,et al. Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice[J]. Hepatology,2011,53(1):253-262. [77] FIDALGO S,IVANOV D K,WOOD S H.Serotonin:from top to bottom[J]. Biogerontology,2013,14(1):21-45. [78] HOYER D,CLARKE D E,FOZARD J R,et al.International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)[J]. Pharmacol Rev,1994,46(2):157-203. [79] CHANG C F,YANG J,ZHAO W M,et al.Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells[J]. Genet Mol Res,2015,14(2):3409-3420. [80] FANG Y,LIU C,SHU B,et al.Axis of serotonin-pERK-YAP in liver regeneration[J]. Life Sci,2018,209:490-497. [81] KIRSCHBAUM M,KARIMIAN G,ADELMEIJER J,et al.Horizontal RNA transfer mediates platelet-induced hepatocyte proliferation[J]. Blood,2015,126(6):798-806. [82] CHEN X Y,ZHAO Y Y,WANG F,et al.microRNAs in liver regeneration[J]. Cell Physiol Biochem,2015,37(2):615-628. [83] ROWLEY J W,OLER A J,TOLLEY N D,et al.Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes[J]. Blood,2011,118(14):e101-e111. |
| [1] | 中国输血协会人类组织抗原专业委员会, 中国输血协会免疫血液学专业委员会. 免疫性血小板输注无效的判定及临床实践专家共识*[J]. 临床输血与检验, 2022, 24(3): 273-278. |
| [2] | 中国人体健康科技促进会妇科内分泌和生育力促进分会, 中国女医师协会输血专业委员会. 自体富血小板纤维蛋白（PRF）治疗宫腔粘连专家共识[J]. 临床输血与检验, 2022, 24(3): 279-284. |
| [3] | 牛思颖, 徐嘉婕, 徐梦瑶, 张议丹, 夏利军, 江淼. 改良型平板流动小室的研制及其在病理血管条件下血小板黏附功能检测中的应用*[J]. 临床输血与检验, 2022, 24(3): 308-314. |
| [4] | 王静, 胡艳, 朱曼, 胡芮维, 张洪为, 黄远帅. 四盐酸精胺抑制血小板活化的初步研究*[J]. 临床输血与检验, 2022, 24(3): 315-319. |
| [5] | 林放, 周谋, 李文丹, 孙宇, 骆美良, 单桂秋. 富血小板纤维蛋白对金黄色葡萄球菌-大肠杆菌混合菌的体外抑菌效果研究*[J]. 临床输血与检验, 2022, 24(3): 320-324. |
| [6] | 杨慕坤, 王子君, 崔广霞, 陈麟凤, 白文佩. 富血小板纤维蛋白对宫腔粘连创面修复的影响研究*[J]. 临床输血与检验, 2022, 24(3): 363-368. |
| [7] | 邵意涵, 朱培元. 血小板的免疫学特性研究进展*[J]. 临床输血与检验, 2022, 24(3): 382-391. |
| [8] | 杨惠宽, 吴千羽, 张嘉仪, 陈小洁, 苑召虎, 魏亚明. miRNA作为血小板储存损伤标志物研究初探*[J]. 临床输血与检验, 2022, 24(2): 176-181. |
| [9] | 李正业, 王浩, 史玮, 高海燕, 马现君. 自体血小板分离回输技术对于不同血小板水平的主动脉夹层患者成分血输注量的影响研究[J]. 临床输血与检验, 2022, 24(2): 207-210. |
| [10] | 刘琴, 徐春芬, 宋婕, 谢松丽, 陈涵薇, 胡红兵. 输注不同治疗剂量血小板在56例急性淋巴细胞白血病患儿中的临床观察*[J]. 临床输血与检验, 2022, 24(2): 218-221. |
| [11] | 黎海燕, 李保才, 李丽君. 血小板无力症的诊治新进展*[J]. 临床输血与检验, 2022, 24(2): 244-248. |
| [12] | 王璐, 姚春艳. 冷藏血小板输注后的清除机制*[J]. 临床输血与检验, 2022, 24(2): 249-252. |
| [13] | 董玉芳, 李萌, 陈雪. 血小板类产品细菌污染的预防、控制相关研究进展[J]. 临床输血与检验, 2022, 24(2): 258-263. |
| [14] | 罗开云, 王淑君, 毛平平, 孙杨子, 齐清, 栾建凤. 不同保存方式对PRP相关生长因子影响的研究*[J]. 临床输血与检验, 2022, 24(1): 70-73. |
| [15] | 赵阳, 胡晓玉, 王超, 陈美梅, 赵娜娜, 於娟, 吕蓉. 安徽合肥地区单采血小板捐献者血样的HPA基因分型[J]. 临床输血与检验, 2022, 24(1): 74-79. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||
