基于AIHA的淋巴细胞亚群及Ca2+-calcineurin-NFAT信号通路的研究进展*

doi:10.3969/j.issn.1671-2587.2022.01.029

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (1): 132-136.DOI: 10.3969/j.issn.1671-2587.2022.01.029

基于AIHA的淋巴细胞亚群及Ca2+-calcineurin-NFAT信号通路的研究进展*

姜浩, 李丽玮, 李志强

200233 上海交通大学附属第六人民医院

收稿日期:2021-09-03 发布日期:2022-01-27
通讯作者: 李丽玮,女,主管技师,硕士,主要从事血型血清学和分子生物学研究,（E-mail）alice_517@qq.com。
共同通信作者：李志强,男,主任医师,硕士研究生导师,主要从事血液系统疾病诊治与临床输血反应研究, （E-mail）kcb039@126.com。
作者简介:姜浩（1995-）,女,江苏南通人,硕士,主要从事内科血液病基础与临床研究,（E-mail）jianghaoyeah@163.com。
基金资助:
*本课题受上海市科学技术委员会科研计划项目（No.20S31902900）资助

Received:2021-09-03 Published:2022-01-27

摘要/Abstract

摘要： 自身免疫性溶血性贫血（AIHA）是一种高度异质性的疾病,其特征为机体内存在抗红细胞（RBC）的自身抗体,导致红细胞破坏增加。发病机制包括无效骨髓代偿,自身免疫耐受的丧失,补体系统、T细胞和B细胞异常,致病性淋巴细胞亚群及细胞因子失调等。目前的多项研究表明,淋巴细胞亚群和Ca2+-calcineurin-NFAT（nuclear factor of activated T cells）信号通路与AIHA的发病机制密切相关。本文着重阐述AIHA相关淋巴细胞亚群及Ca2+-calcineurin-NFAT信号通路在疾病发生发展中的作用。

关键词: 自身免疫性溶血性贫血, B淋巴细胞, T淋巴细胞, Ca2+-calcineurin-NFAT信号通路

中图分类号:

R556

姜浩, 李丽玮, 李志强. 基于AIHA的淋巴细胞亚群及Ca2+-calcineurin-NFAT信号通路的研究进展*[J]. 临床输血与检验, 2022, 24(1): 132-136.

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