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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 661-663.DOI: 10.3969/j.issn.1671-2587.2019.06.028

• 临床输血 • 上一篇    下一篇

3 078例住院患者血型不规则抗体检测结果与其产生的影响因素分析

王磊   

  1. 232007 淮南市第一人民医院输血科
  • 收稿日期:2019-01-17 出版日期:2019-12-20 发布日期:2019-12-25
  • 作者简介:王磊（1984-）,男,安徽淮南人,主管技师,学士,主要从事临床输血相关工作,（Tel）0554-3320821 （E-mail）190169283@qq.com。

Irregular Antibodies to Blood Types and Their Influencing Factors in 3 078 inpatients

WANG Lei   

  1. Department of Blood Transfusion,Huainan First People's Hospital 232007
  • Received:2019-01-17 Online:2019-12-20 Published:2019-12-25

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摘要： 目的 通过对住院患者血清不规则抗体的检测,分析不规则抗体分布情况以及患者不同性别、年龄、输血史、妊娠史对抗体产生的影响。方法 采集3 078例住院患者血液标本,应用聚凝胺法进行不规则抗体筛查,应用谱细胞进行不规则抗体鉴定,应用统计学方法对结果和影响因素进行分析。结果 3 078例住院患者不规则抗体筛查阳性32例,阳性比率10.396‰。筛查阳性标本经鉴定,同种抗体占84.375%、自身抗体占15.625%;Rh系统占43.75%、MNSs系统占15.625%、Lewis系统占12.50%;IgG类占62.50%、IgM类占31.25%、IgM/IgG联合类占6.25%。单因素分析结果显示,女性、年龄≥60岁、有输血史、有妊娠史患者的不规则抗体阳性率分别高于男性、年龄<60岁、无输血史、无妊娠史患者,其阳性率差异均具有统计学意义（P<0.05）。多因素Logistic回归分析结果显示,年龄（≥60岁）、有输血史和有妊娠史为不规则抗体产生的主要影响因素（P<0.05）。结论 淮南市第一人民医院住院患者血清不规则抗体的产生与患者年龄、输血史、妊娠史相关。

关键词: 不规则抗体, 输血史, 妊娠史, 谱细胞

Abstract: Objective To analyze the distribution of irregular antibodies against blood types and the influencing factors of gender,age,blood transfusion or pregnancy history in hospitalized patients.Methods The blood samples of 3078 inpatients were collected,the manual polybrene tests were used for irregular antibody screening,the panel cells were used for irregular antibody identification to analyze the results and influencing factors. Results Thirty-two cases of 3078 inpatients were found to carry irregular antibodiesaccouted for with the positive rate of 10.396‰. Among them,the alloantibodies accounted for 84.38% whereas the autoantibodies,15.625%,after identification.The antibodies to Rh,MNSs and Lewis blood groups accounted for 43.75%,15.63% and 12.50%,respectively. The frequencies of IgG,IgM and IgM-IgG classes were 62.50%,31.25% and 6.25%,respectively. Univariate analyses showed that the positive rates of irregular antibodies in female,patients aged over 60 years,blood transfusion or pregnancy history were significantly increased when compared with the other patients investigated （P<0.05）. Multivariate logistic regression analysis showed that age （over 60）,blood transfusion and pregnancy were the main influencing factors of irregular antibody production （P<0.05）. Conclusion The level of serum irregular antibodies in hospitalized patients of Huainan district was positively related to age,history of blood transfusion and pregnancy.

Key words: Irregular antibody, History of Blood transfusion, History of pregnancy, Panel cells

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