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临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (2): 203-205.DOI: 10.3969/j.issn.1671-2587.2020.02.022

• 临床检验 • 上一篇    下一篇

慢性乙型肝炎及肝硬化患者HBsAg和HBV DNA定量检测的临床意义

辛菊梅   

  1. 224600 江苏省盐城市响水县人民医院感染科
  • 收稿日期:2018-06-14 出版日期:2020-04-20 发布日期:2020-04-16
  • 作者简介:辛菊梅（1969-）,女,江苏盐城人,主治医师,学士,主要从事感染科工作,（Tel）15718833051。

Clinical Significance of HBsAg and HBV DNA Quantitation in Patients with Chronic Hepatitis B and HBV-Related Liver Cirrhosis

XIN Ju-mei   

  1. Department of Infectious Diseases,Xiangshui Hospital of Yancheng,Jiangsu 224600
  • Received:2018-06-14 Online:2020-04-20 Published:2020-04-16

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摘要： 目的 探讨慢性乙型肝炎及其肝硬化患者HBsAg、HBV DNA定量检测的临床意义。方法 回顾性分析74例慢性乙型活动性肝炎患者（亦为无肝硬化患者组,A组）、39例代偿期肝硬化患者（B组）及39例失代偿期肝硬化患者（C组）的血清HBsAg、HBV DNA定量水平,并进行统计分析。结果 随着肝硬化程度的加重,HBsAg与HBV DNA定量水平逐步降低（P<0.05）。三组患者的HBsAg和HBV DNA定量水平为正相关关系（r=0.614,P<0.001）但在代偿期肝硬化组（r=0.267,P=0.101）、失代偿期肝硬化组（r=0.232,P=0.155）两者无相关性。HBsAg和HBV DNA定量水平与肝硬化严重程度呈负相关。结论 HBsAg定量水平在慢性乙型肝炎、代偿期肝硬化、失代偿期肝硬化患者中随着肝硬化程度的加重而逐渐降低,且HBsAg与HBV DNA定量水平之间呈正相关,非绝对平行。

关键词: HBsAg, HBV DNA, 慢性乙型肝炎, 肝硬化

Abstract: Objective To investigate the clinical significance of quantitative detection of HBsAg and HBV DNA in the patients with chronic hepatitis B and liver cirrhosis. Methods The levels of serum HBsAg and HBV DNA were retrospectively analyzed in 74 patients with chronic active hepatitis B without liver cirrhosis （group A）,39 cases of cirrhosis at compensated stage （group B）,and 39 cases at decompensated stage （group C）. Results The loads of HBsAg and HBV DNA gradually decreased with the disease exacerbation（P<0.05）; the quantitative levels of HBsAg and HBV DNA were closely correlated in patients of the three group（r=0.614,P<0.001）. The level of HBsAg,however,did not show any correlation with that of HBV DNA in the patients of groups B（r=0.267,P=0.101） and C（r=0.232,P=0.155）,in which the levels of HBsAg and HBV DNA exhibited a negative correlation with the severity of liver cirrhosis. Conclusion sThe level of HBsAg gradually decreases with the severity of liver cirrhosis in the patients with chronic hepatitis B,compensated cirrhosis,and decompensated cirrhosis. The load of HBsAg is positively correlated with that of HBV DNA.

Key words: HBsAg, HBV DNA, Chronic hepatitis B, Liver cirrhosis

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