G6PD缺乏症在输血医学中的研究进展

doi:10.3969/j.issn.1671-2587.2025.02.017

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (2): 261-266.DOI: 10.3969/j.issn.1671-2587.2025.02.017

G6PD缺乏症在输血医学中的研究进展

卿芸, 黄霞

重庆市血液中心,重庆 400052

收稿日期:2024-12-06 出版日期:2025-04-20 发布日期:2025-04-17
通讯作者: 黄霞,主要从事血液质量管理和血液安全监测体系建立研究,（E-mail）xiahuangyy@163.com。
作者简介:卿芸,主要从事临床输血与血液质量控制工作,（E-mail）qingyun_windcome@126.com.cn。

Advancements in the Study of G6PD Deficiency in Transfusion Medicine

QING Yun, HUANG Xia

Chongqing Blood Center, Chongqing 400052

Received:2024-12-06 Online:2025-04-20 Published:2025-04-17

摘要/Abstract

摘要： 葡萄糖-6-磷酸脱氢酶（G6PD）缺乏会导致红细胞在氧化应激反应中遭受破坏。尽管目前对健康献血者进行G6PD缺乏的筛查并不是常规做法,但有文献报道输入G6PD缺乏症红细胞可导致溶血和其他不良事件。此外,一些特殊的患者群体可能更容易出现与G6PD缺陷红细胞输血相关的并发症。本文就G6PD缺乏症发病机制研究及其在输血实践中的临床挑战进行综述,以期提高相关人群输血的有效性和安全性。

关键词: G6PD缺乏, 献血者, 输血, 溶血

Abstract: Deficiency of glucose-6-phosphate dehydrogenase (G6PD) can lead to the destruction of red blood cells during oxidative stress responses. Although screening for G6PD deficiency is not currently a routine practice in healthy blood donors, there are reports in the literature that transfusion of RBCs from individuals with G6PD deficiency can lead to hemolysis and other adverse events. Moreover, certain patient populations may be more susceptible to complications associated with the transfusion of G6PD-deficient RBCs. This article reviews the pathogenesis of G6PD deficiency and its clinical challenges in transfusion practice, aiming to improve the effectiveness and safety of blood transfusion for relevant populations.

Key words: G6PD deficiency, Blood donors, Transfusion, Hemolysis

中图分类号:

R457.1R556.6

卿芸, 黄霞. G6PD缺乏症在输血医学中的研究进展[J]. 临床输血与检验, 2025, 27(2): 261-266.

QING Yun, HUANG Xia. Advancements in the Study of G6PD Deficiency in Transfusion Medicine[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 261-266.

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G6PD缺乏症在输血医学中的研究进展

Advancements in the Study of G6PD Deficiency in Transfusion Medicine

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