Rh血型系统分子调控机制研究进展与临床应用实践

doi:10.3969/j.issn.1671-2587.2025.05.019

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (5): 712-716.DOI: 10.3969/j.issn.1671-2587.2025.05.019

Rh血型系统分子调控机制研究进展与临床应用实践

李景琦, 祁术元, 耿凌云

首都医科大学附属首都儿童医学中心输血科,北京 100020

收稿日期:2025-09-02 修回日期:2025-09-12 出版日期:2025-10-20 发布日期:2025-10-11
通讯作者: 耿凌云,主要从事儿科临床及输血管理研究工作,（E-mail）glydoctor@vip.sina.com。
作者简介:李景琦,主要从事儿科临床及输血管理研究工作,（E-mail）949240355@qq.com。

Research Progress on the Molecular Regulatory Mechanism of the Rh Blood Group System and Its Clinical Application

LI Jingqi, QI Shuyuan, GENG Lingyun

Capital Center for Children's Health,Capital Medical University, Beijing 100020

Received:2025-09-02 Revised:2025-09-12 Online:2025-10-20 Published:2025-10-11

摘要/Abstract

摘要： Rh血型系统是具有临床意义的血型系统之一,Rh血型系统不相容性输血可引起同种免疫反应,导致患者发生溶血性输血反应、胎儿及新生儿溶血病（HDFN）等严重不良反应,威胁患者生命健康。近年有关RHD以及RHCE基因变异的前沿研究取得显著进展,不仅为输血方案的革新注入动力,也为血液资源管理提供了新思路。本文通过介绍Rh血型系统抗原分布、分子基础研究、临床应用及技术创新方面的最新进展,旨在为优化输血策略,提升输血安全及疗效提供理论参考和实验指导。

关键词: Rh血型系统, 基础研究, 同种抗体, 变异体, 精准输血

Abstract: The Rh blood group system is one of the most clinically significant blood group systems. Incompatibility in this system can lead to alloimmunization, resulting in severe adverse reactions such as hemolytic transfusion reactions in patients and hemolytic disease of the fetus and newborn (HDFN), which threaten patient lives. Recent cutting-edge research on RHD and RHCE variants has yielded significant progress, providing not only an impetus for innovating transfusion protocols but also novel strategies for the management of blood resources. This article reviews the latest advances in the distribution of Rh antigens, their molecular basis, clinical applications, and associated technological innovations, with the aim of optimizing transfusion strategies to enhance safety and efficacy.

Key words: Rh blood group system, Basic research, Alloantibody, Variant, Precision transfusion

中图分类号:

R457

李景琦, 祁术元, 耿凌云. Rh血型系统分子调控机制研究进展与临床应用实践[J]. 临床输血与检验, 2025, 27(5): 712-716.

LI Jingqi, QI Shuyuan, GENG Lingyun. Research Progress on the Molecular Regulatory Mechanism of the Rh Blood Group System and Its Clinical Application[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 712-716.

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Rh血型系统分子调控机制研究进展与临床应用实践

Research Progress on the Molecular Regulatory Mechanism of the Rh Blood Group System and Its Clinical Application

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