儿童血小板抗体与自身免疫失调的相关因素分析*

doi:10.3969/j.issn.1671-2587.2021.06.007

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (6): 708-710.DOI: 10.3969/j.issn.1671-2587.2021.06.007

• 妇产科儿科输血专题（二） • 上一篇下一篇

儿童血小板抗体与自身免疫失调的相关因素分析^*

王静, 王成云, 顾萍, 张帆, 潘秋辉

200127 国家儿童医学中心上海交通大学医学院附属上海儿童医学中心

收稿日期:2021-06-12 出版日期:2021-12-20 发布日期:2021-12-21
通讯作者: 潘秋辉,女,研究员,博士,主要从事肿瘤的基因诊断、基础研究和靶向药物研发,（E-mail） panqiuhui@scmc.com.cn。
作者简介:王静（1968-）,女,上海人,主任技师,硕士,主要从事儿童临床输血及输血疗效及儿童凝血功能研究,（E-mail） wjeney@163.com。
基金资助:
*本课题受国家自然科学基金面上项目（No.81871727）资助

Analysis of Related Factors between Platelet Antibody and Autoimmune Disorder in Children

WANG Jing, WANG Cheng-yun, GU Ping, et al

Department of Transfusion, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, National Children's Medical Center 200127

Received:2021-06-12 Online:2021-12-20 Published:2021-12-21

摘要/Abstract

摘要： 目的对自身免疫性血小板减少症患儿进行血小板抗体检测,探讨其与自身免疫失调的相关性。方法回顾分析2018年1月~2020年12月上海儿童医学中心自身免疫性疾病患儿血小板抗体标本检测结果,采用Graphpad prism 8统计软件对检测结果进行统计分析。结果 94例自身免疫性疾病患者中,血小板抗体阳性率为50%,自身抗体阳性率为36%,血小板抗体阳性率高于自身抗体。经统计学分析,血小板抗体与自身抗体存在相关性,但两者在自身免疫性疾病中检测结果无显著性差异。结论自身免疫失调性疾病进展期,体内血小板抗体可与自身抗体同时存在,二者都是导致自身免疫性血小板减少的原因。

关键词: 血小板抗体, 自身免疫性疾病, 耐受性, 自身免疫性血小板减少症

Abstract: Objective To detect platelet antibody in children with autoimmune thrombocytopenia and explore its correlation with autoimmune disorders. Methods The results of platelet antibody were retrospectively analyzed in children with autoimmune diseases of Shanghai Children's Medical Center from January 2018 to December 2020 and the results were statistically analyzed by Graphpad prism 8 statistical software. Results In 94 children with autoimmune diseases, the positive rate of platelet antibody was 50%, the positive rate of autoantibody was 36%, and the positive rate of platelet antibody was higher than that of autoantibody. There was correlation between platelet antibody and autoantibody, but no significant difference between them in autoimmune diseases, according to statistical analysis. Conclusion In the advanced stage of autoimmune disorders, platelet antibodies and autoantibodies can exist simultaneously, both of which are the causes of autoimmune thrombocytopenia.

Key words: Platelet antibody, Autoimmune diseases, Tolerance, Autoimmune thrombocytopenia

中图分类号:

R593.2R558⁺2

王静, 王成云, 顾萍, 张帆, 潘秋辉. 儿童血小板抗体与自身免疫失调的相关因素分析^*[J]. 临床输血与检验, 2021, 23(6): 708-710.

WANG Jing, WANG Cheng-yun, GU Ping, et al. Analysis of Related Factors between Platelet Antibody and Autoimmune Disorder in Children[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(6): 708-710.

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儿童血小板抗体与自身免疫失调的相关因素分析^*

Analysis of Related Factors between Platelet Antibody and Autoimmune Disorder in Children

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