关键词: 新生儿溶血病, 血常规, 生化检查, 基层医院

Abstract: Objective To explore the value of blood examination results in diagnosing hemolytic disease of newborn in primary hospitals. Methods Neonates cases born and hospitalized in the First Affiliated Hospital of University of Science and Technology of China from August 2020 to May 2023 were collected and analyzed. All the cases were grouped by clinical diagnosis. The clinical symptoms, blood routine and biochemical examination results were analyzed. The area under the curve (AUC) was used to evaluate the diagnostic efficiency of the combination index by logistic regression. Results The statistical analysis shows that ABO incompatibility were more likely to occur in O-A setting Neonates. Compared with HDN patients, The levels of white blood cell count (WBC), platelet count (PLT), red blood cell distribution width (RDW), erythrocyte mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), blood glucose (GLU), globulin (GLO) and neonatal bilirubin (NBIL) in HDN group were significantly higher than non-HDN group. Red blood cell count (RBC), hemoglobin (HB) and Red blood cell specific volume (HCT) were significantly lower than those in the HDN group. In order to find a more convenient and efficient auxiliary diagnosis method, the blood examination was combined and the diagnosis efficiency of HDN was increased to 0.77 (0.72~0.78, P<0.05). Conclusion The combination index of blood examination results has well performance at early diagnosis of HDN. It provides a new idea for screen or/and diagnosis of hemolytic disease of newborn in primary hospitals.

Key words: Hemolytic disease of newborn, Blood routine examination, Biochemical examination, Primary hospitals