血清同型半胱氨酸在心肌梗死介入治疗中的临床应用

doi:10.3969/j.issn.1671-2587.2018.01.023

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (1): 64-67.DOI: 10.3969/j.issn.1671-2587.2018.01.023

血清同型半胱氨酸在心肌梗死介入治疗中的临床应用

龙吴坚, 李昭祺, 钟义

571300 海南省文昌市人民医院心内科

收稿日期:2017-08-28 出版日期:2018-02-20 发布日期:2018-02-28
作者简介:龙吴坚（1982-）,女,海南文昌人,主治医师,学士,主要从事心血管疾病临床工作,（Tel）18928761935（E-mail）lwuj82@163.com。

The Clinical Application of Homocysteine in the Interventional Treatment of Myocardial Infarction

LONG Wu-Jian, LI Zhao-qi, ZHONG Yi

Department of Cardiology,Wenchang people's Hospital 571300

Received:2017-08-28 Online:2018-02-20 Published:2018-02-28

摘要/Abstract

摘要： 目的探讨血清同型半胱氨酸（homocysteine,Hey）在心肌梗死介入治疗中的临床意义。方法选择2014年6月~2016年1月因急性心肌梗死在本院进行介入治疗的56例患者为治疗组,检测治疗前后高脂血症及血清Hey等指标,并与60例健康者（对照组）进行比较。结果治疗组术前的血压、体重指数（BMI）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（LDL-C）、低密度脂蛋白胆固醇（HDL-C）、血糖及Hcy均高于对照组,差异有统计学意义（P<0.05）;治疗组术后Hcy水平低于术前Hcy水平,但高于对照组,差异有统计学意义（P<0.05）;多因素Logistic回归分析结果显示血清Hcy是引发AMI的独立危险因素。结论血清同型半胱氨酸在心肌梗死介入治疗后水平下降,与冠心病严重程度相关,有助于了解心肌梗死的病情及预后。

关键词: 介入治疗, 同型半胱氨酸, 心肌梗死

Abstract: Objective To investigate the clinical application of homocysteine in the interventional treatment of myocardial infarction. Method 156 patients cured in our hospital treated by percutaneous coronary intervention with acute myocardial infarction from 2014 June to 2016 January were chosen as the treatment group,before and after treatment hyperlipidemia,homocysteine and other indicators were detected and compared with 60 healthy persons （the control group）. Results The levels of blood pressure、BMI、TG、TC、LDL-C、HDL-C、GLU and Hcy in the treatment group before the operation were higher than the control group,the difference was statistically significant （P<0.05）; The levels of Hcy in the treatment group after the operation were lower than before the operation,but higher than the control group,the difference was statistically significant（P<0.05）; multivariate Logistic regression analysis showed that Hcy was an independent risk factor for AMI. Conclusion The Hcy level decreased after acute myocardial infarction PCI,is related to the severity of coronary heart disease,it is helpful to understand the condition and prognosis of myocardial infarction.

Key words: Interventional treatment, Homocysteine, Myocardial infarction

中图分类号:

R542.2⁺2R446.11

龙吴坚, 李昭祺, 钟义. 血清同型半胱氨酸在心肌梗死介入治疗中的临床应用[J]. 临床输血与检验, 2018, 20(1): 64-67.

LONG Wu-Jian, LI Zhao-qi, ZHONG Yi. The Clinical Application of Homocysteine in the Interventional Treatment of Myocardial Infarction[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2018, 20(1): 64-67.

参考文献

1 张平. 老年急性心肌梗塞死患者行急诊经皮冠状介入的临床疗效[J].世界最新医学信息文摘,2015,15(58):47-48.
2 徐素仿,徐元宏. 急性脑梗塞患者同型半胱氨酸、D–二聚体及纤维蛋白原检测及意义[J]. 临床输血与检验,2013,15(3):241-242.
3 Wang L,Li H,Zhou Y,et al. Low-dose B vitamins supplementation ameliorates cardiovascular risk:a double-blind randomized controlled trial in healthy Chinese elderly[J]. Eur J Nutri,2015,54(3):45-464.
4 陆再英. 内科学[M]. 第7版.北京:人民卫生出版社,2010.
5 Eckel R H,Cornier M A. Update on the NCEP ATP-III emerging cardiometabolic risk factors[J]. Bmc Med,2014,12(1):1-9.
6 许寅宏,徐恩.血清同型半胱氨酸与脑梗死患者颈动脉粥样硬化斑块稳定性的关系[J]. 中风与神经疾病杂志,2014,7(31):603-605.
7 Geller V,Friger M,Sela B A,et al. Elevated homocysteine level in siblings of patients with schizophrenia[J]. Psychiatry Res,2013,210(3):769-772.
8 Rahman A,Gupta R D,Quraishi F A,et al. Relationship Between Homocysteine and Ischemic Stroke[J]. Journal of Medicine,2013,14(1):47-51.
9 任孔华,赵金凤,姜小华. 等. 急性心肌梗塞介入治疗前后 Hcy 变化及临床意义[J]. 中国卫生检验杂志,2015,21(25):3601-3603.
10 Chowers Y,Sela B A,Holland R,et al. Iconography :Increased levels of homocysteine in patients with Crohn’s disease are related to folate levels[J]. Neurol Sci,2014,35(2):215-220.
11 石秀芳,孙峰,雷婷,等. 冠心病患者检测血浆氨基末端脑钠肽前体及同型半胱氨酸的临床意义[J]. 临床输血与检验,2016,18(4):362-364.
12 严湘红,潘建华. 同型半胱氨酸与急性心肌梗死及稳定型心绞痛的相关分析[J]. 国际检验医学杂志,2013,34(3):367-368.
13 Gu B Y,Ji H C,Su H L,et al. Analysis of Serum Homocysteine and Risk of Coronary Heart Disease in Patients with Pseudoexfoliation Syndrome[J]. Journal of the Korean Ophthalmological Society,2016,57(3):461-467.
14 钟少惠,洪晓鹏.同型半胱氨酸与急性心肌梗死的相关性研究[J].河北联合大学学报,2012,14(3) :378-379 .

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血清同型半胱氨酸在心肌梗死介入治疗中的临床应用

The Clinical Application of Homocysteine in the Interventional Treatment of Myocardial Infarction

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