Abstract: Objective To retrospectively analyze the distribution of antibodies and results of treatments in 8 cases of intrauterine transfusions for positive irregular antibodies and to provide a reference for the clinic treatments. Methods Irregular antibodies and their titers were detected in 8 maternal blood samples and fetal hemoglobin contents and hematocrit were measured with Sysmex xs-800i (five categories) . Results Four of 8 cases of Rh blood group antibodies were found, including one case of anti-CcEe, two cases of anti-D, and one case of anti-DC antibodies. There were 4 pregnant women who showed anti-M antibodies. Eight cases received 27 times of intrauterine blood transfusion, resulting in a notable improvement of fetal hemoglobin content or hematokrit. Correspondingly, the maternal irregular antibody titers were decreased in different degree. Six of the 8 fetuses survived. Conclusion Antibody screening and titer monitoring are required in those who have the history of transfusion, pregnancy, and/or habitual abortions. Ultrasound examination and implement of standardized intrauterine transfusion may improve the environment of the fetal growth .

Key words: Fetal anemia, Intrauterine transfusion, Irregular antibody