Effect of Fecal Microecological Transplantation Combined with Sulfasalazine on Serum Inflammatory Factors and T Cell Subsets in Patients with Ulcerative Colitis

doi:10.3969/j.issn.1671-2587.2021.04.019

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2021, Vol. 23 ›› Issue (4): 497-501.DOI: 10.3969/j.issn.1671-2587.2021.04.019

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Effect of Fecal Microecological Transplantation Combined with Sulfasalazine on Serum Inflammatory Factors and T Cell Subsets in Patients with Ulcerative Colitis

SUN Li-li, XUE Qing

Department of Health Care, Taigong Sanatorium, Wuxi, Jiangsu 21400

Received:2020-03-26 Published:2021-08-18

Abstract

Abstract: Objective To investigate the effects of fecal micro-ecological transplantation combined with sulfasalazine on serum inflammatory factors and T-cell subsets in patients with ulcerative colitis. Methods a study of 90 patients with UC admitted to our hospital from June 2018 to December 2019, the observation group was given fecal microecological transplantation combined with sulfasalazine, and the control group was given conventional treatment to observe serum inflammatory factors, Mayo score, T cell subsets and clinical efficacy before and after treatment in UC patients. Results The effective rate of the observation group was 95.5%. The effective rate of the observation group was significantly better than that of the control group, and the Mayo score was significantly lower than that before treatment (P<0.05). Inflammation of CRP, TNF-α, IL-6, etc. The factors were significantly decreased (P<0.05), and better than the control group (P<0.05). After treatment, the CD₄⁺ increased and the CD₄⁺/CD₈⁺ ratio increased (P<0.05). The observation group was significantly higher than the control group (P<0.05). Conclusions FMT combined with sulfasalazine can improve the immune status of T cell subsets, reduce the inflammatory response, and achieve the effect of treating UC by establishing the normal intestinal flora. It has certain safety.

Key words: Fecal microecological transplantation, Ulcerative colitis, Inflammatory factors, T cell subsets

CLC Number:

R574

SUN Li-li, XUE Qing. Effect of Fecal Microecological Transplantation Combined with Sulfasalazine on Serum Inflammatory Factors and T Cell Subsets in Patients with Ulcerative Colitis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(4): 497-501.

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Effect of Fecal Microecological Transplantation Combined with Sulfasalazine on Serum Inflammatory Factors and T Cell Subsets in Patients with Ulcerative Colitis

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