Research Progress and Application Prospect of Hemoglobin-based Oxygen Carriers

doi:10.3969/j.issn.1671-2587.2024.02.019

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (2): 282-288.DOI: 10.3969/j.issn.1671-2587.2024.02.019

Research Progress and Application Prospect of Hemoglobin-based Oxygen Carriers

LI Yang^1,2, YANG Mingfeng^1,2, WANG Ying^1,2, ZHANG Jian³, LIU Jiaxin⁴, SUN Baoliang^1,2

¹Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000;
²Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117;
³Institute of Microcirculation, Chinese Academy of Medical Sciences, Beijing 100005;
⁴Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, Chengdu 610052

Received:2024-01-10 Online:2024-04-20 Published:2024-04-23

Abstract

Abstract: Red blood cell transfusion has been widely used in trauma treatment, surgery, anemia treatment, war wound emergency treatment and other aspects, but there are still problems such as shortage of blood resources, short storage period, cross-matching before transfusion, and possible transmission of pathogens through blood. Hemoglobin-based oxygen carriers (HBOCs) are a class of soluble nano-oxygen carriers prepared by chemical modification of matrix-free hemoglobin, which can replace red blood cells to transport oxygen to organs and tissues in the body. HBOCs have the characteristics of no blood group and virus transmission risk, long storage, and instant use, so they are also known as red blood cell substitutes. This paper aims to review the research progress of HBOCs, and explore their application prospects in organ preservation, cerebral ischemia, tumor treatment and other treatments in addition to the replacement of red blood cell transfusion.

Key words: Red Blood Cell Substitutes, Hemoglobin oxygen carrier, Trauma, Anemia, Organ preservation, Cerebral ischemia, Tumor

CLC Number:

R457

LI Yang, YANG Mingfeng, WANG Ying, ZHANG Jian, LIU Jiaxin, SUN Baoliang. Research Progress and Application Prospect of Hemoglobin-based Oxygen Carriers[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(2): 282-288.

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Research Progress and Application Prospect of Hemoglobin-based Oxygen Carriers

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