Abstract: Objective Statistical analysis the antibody specificity and transfusion of patients due to blood transfusion of red blood cells of irregular antibodies,explore the measures to promote the saftey and effectiveness of blood transfusion. Methods 22 306 cases of blood transfusion patient was collected from January 2013 to December 2015,to statistics analysis the red blood cells of irregular antibodies screening evaluation test Results and the red blood cells of irregular antibody specificity. Results There were 22 215 cases which were negative for irregular antibody in 22 306 cases of blood transfusion samples,and 41 cases were positive after blood transfusion,at a rate of 0.18% （41/22 215）. Specific antibodies were found in 36 cases,Rh system antibodies were detected in 29 cases,accounting for 80.56% （29/36）; Lewis system antibodies were found in 5 cases,accounting for 13.88% （5/36）; Kidd system antibodies were found in 2 cases,accounting for 5.56% （2/36）. Among 36 patients,14 patients produce irregular antibody with transfusion of red blood cell,there are 4 cases of frozen plasma infusion alone or platelets,18 cases of infusion contains a variety of blood composition. Conclusion Irregular antibody screening and identification of the Rh system antigen in blood donors and recipients before blood transfusion,and transfusion of the suitable blood which can significantly reduce the produce of irregular antibodies,was an important means to ensure the safety of clinical blood transfusion.

Key words: Irregular antibody, Screening, Transfusion