Abstract: Objective To investigate the value of homocysteine (Hcy) in prognosis of the invasion of (UCs) myometrium in urothelial cell carcinoma. Methods The difference of Hcy between invasive and non-invasive UCs patients was analyzed in 57 patients with UCs; To analyze the difference of Hcy level between the patients with infiltrative UCs and those with non-myometrial infiltration; The level of Hcy was used to determine whether UCs has myometrial infiltration or not to draw the operating curve of subjects ROC; Analysis of the relationship between myometrial infiltration and other pathological parameters in patients with UCs. Results The difference of Hcy between invasive and non-invasive UCs patients was statistically significant (t=2.103, P=0.04); There was significant difference in Hcy between UCs patients with myometrial infiltration and without(t=3.109, P=0.003); The Hcy value of 11.95 can be used as the best cut-off point for myometrium infiltration in UCs patients; Myometrial infiltration in UCs patients was correlated with age≥70 and Hcy level (P<0. 05); Conclusion The level of Hcy can helpful to judge whether there is myometrial infiltration in UCs patients.

Key words: Urothelial cell carcinoma, Homocysteine, Myometrial infiltration