• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 674-680.DOI: 10.3969/j.issn.1671-2587.2025.05.014

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Research Progress on Gut Microbial Enzymes in the Preparation of ABO Universal Red Blood Cells

HE Li, WANG Yongjun   

  1. Department of Blood Transfusion, Xiangya Second Hospital of Central South University, Changsha, 410011
  • Received:2025-09-01 Revised:2025-09-12 Online:2025-10-20 Published:2025-10-11

Abstract: The technology for preparing ABO universal red blood cells (RBCs) not only effectively alleviates blood supply shortages caused by the uneven distribution of ABO blood types among donors, but also significantly reduces resource consumption from pre-transfusion testing and transfusion risks due to human operational errors. It represents a breakthrough technology of significant clinical value in the field of transfusion medicine. Among these approaches, enzymatic conversion is currently the only method for preparing ABO-universal RBCs that has undergone preliminary clinical validation as safe and effective. However, screening for highly efficient and specific enzymes suitable for this purpose remains a critical challenge that requires urgent resolution. This review focuses on the application value of gut microbial enzymes in the preparation of ABO universal RBCs. It systematically elaborates on the following aspects: the characteristics of ABO blood group antigens, the principles and clinical trial progress of enzymatic preparation of ABO universal RBCs, gut microbial enzymes degrading A and B antigens, and the exploration of such enzymes in the production of ABO-universal RBCs.

Key words: ABO blood group, Universal red blood cells, Gut microbiota, Microbial enzymes, Enzyme-converted group O RBCs

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