Abstract: Objective To determine serum interleukin (IL)-10 and thymidine kinase 1 (TK1) levels in children with acute lymphoblastic leukemia (ALL), and analyze the relationship between the two and risk stratification in ALL children. Methods A total of 100 ALL children admitted at hospital from May 2018 to May 2021 were selected. All pediatric patients were evaluated for risk stratification, and we investigated the baseline data. Serum IL-10, TK1, as well as other laboratory indexes were detected. The expression of serum IL-10 and TK1, and the relationship between the two levels and risk stratification were performed. Results ALL children were evaluated for risk stratification, of which 24 cases had standard-risk, 50 cases had medium-risk and 26 cases had high-risk, accounting for 24.00%, 50.00% and 26.00% respectively. There was no statistically significant difference between the three groups of baseline data (P>0.05). The levels of IL-10, TK1 and white blood cell (WBC) count in high-risk group were higher than those in standard-risk group and medium-risk group, and there was a statistically significant differences between the two groups(P<0.05). Using Kendall's tau-b, we found positive correlation between serum IL-10, TK1 and WBC count were associated with risk stratification in ALL children (r>0, P<0.05). Multivariate Logistic regression analysis revealed that when serum IL-10, TK1 and WBC counts decreased, the probability of risk stratification in ALL children was 7.128 times, 13.572 times and 1.665 times, respectively, compared with high-risk group (P<0.05). Conclusions erum IL-10 and TK1 are abnormally expressed in ALL children and are positively correlated with risk stratification.

Key words: Acute lymphoblastic leukemia, Risk stratification, Interleukin-10, Thymidine kinase-1, Correlation