Abstract: Plasma is a commonly used component in clinical blood transfusion, primarily for supplementing coagulation factors to prevent or treat bleeding or bleeding tendencies caused by coagulation factor deficiencies. Convalescent plasma therapy have broadened the clinical application of plasma infusion. Research has shown that plasma infusion can also alleviate skin diseases and promote corneal regeneration. In animal experiments, it has been discovered that young plasma can combat aging and alleviate clinical manifestations of aging-related diseases by restoring autophagy, inhibiting apoptosis, reducing oxidative stress, and exerting anti-inflammatory effects. This article summarizes the progress of animal experimental research on the expanded applications of plasma and its related components except convalescent plasma therapy. It explores the potential molecular mechanisms underlying these expanded plasma applications, which provides foundation for advancing the commercialization of plasma components and the development of transfusion medicine treatment technology.

Key words: Plasma, Heterochronic parabiosis, Expansion applications, Proteomics