Abstract: Objective To explore the value of combined determination of β-catenin/cadherin together with serum uric acid for the prognosis of diabetic nephropathy （DN）. Method sOne hundred and forty-six DN patients were selected in the past one year and divided into the groups of CKD stage 1~3 （88 cases）and CKD stage 4~5 （58 cases）according to glomerular filtration rate （GFR）and serum creatinine level （Scr）. Logistic analysis was used to explore the independent risk factors affecting the renal function of DN and the clinical significance of β-catenin/cadherin detection combined with serum uric acid （UA）for evaluation of renal function. Results No significant difference of the assessment of DN prognosis was noted in gender,age,BMI,smoking history,FPG,HbA1C,TC,TG,HDL-C and LDL-C levels （P>0.05）. The levels of serum UA,urinary protein,HMOA-IR,urinaryβ-catenin/cadherin varied significantly in DN patients with different prognosis （P<0.05）. Logistic regression analysis showed that the concentrations of UA,urinary protein,HMOA-IR,and β-catenin/cadherin were independent risk factors which affect renal function. The patients with CKD stage 1~3 presented a normal result of the combination detection of UA andβ-catenin/cadherin（P<0.05）whereas the patient with CKD stage 4~5 demonstrated a high value of the combination tests（P<0.05）. Conclusion sTheβ-catenin/cadherin and serum UA are independent risk factors of renal disfunction and a combined detection of the three markers is clinically valuable in the prognosis of DN patients.

Key words: Insulin, resistance, Diabetic, nephropathy, Cell, adhesion, factor, Serum, uric, acid, Prognosis